ReviewFrontiers in human neuroscience2013
Ephaptic communication in the vertebrate retina.
Review in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons.bioRxiv : the preprint server for biology · 2025Article
- Reproducible Human Neural Circuits Printed with Single-Cell Precision Reveal the Functional Roles of Ephaptic Coupling.ACS nano · 2025Article
- The structure, function, and distribution of gap junctions in the retina: Life cycle in health and disease.Journal of cell communication and signaling · 2025Review
- An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Thermal effects and ephaptic entrainment in Hodgkin-Huxley model.Scientific reports · 2024Article
- The retinal pigment epithelium displays electrical excitability and lateral signal spreading.BMC biology · 2023Article
- Nonquantal transmission at the vestibular hair cell-calyx synapse: KProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Synaptic spinules are reliable indicators of excitatory presynaptic bouton size and strength and are ubiquitous components of excitatory synapses in CA1 hippocampus.Frontiers in synaptic neuroscience · 2022Article
- Presynaptic coupling by electrical synapses coordinates a rhythmic behavior by synchronizing the activities of a neuron pair.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Molecular mechanisms underlying selective synapse formation of vertebrate retinal photoreceptor cells.Cellular and molecular life sciences : CMLS · 2020Review
- KNeuroscience · 2020Article
- Slow periodic activity in the longitudinal hippocampal slice can self-propagate non-synaptically by a mechanism consistent with ephaptic coupling.The Journal of physiology · 2019Article
- LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors.Cell reports · 2018Article
- Two Forms of Electrical Transmission Between Neurons.Frontiers in molecular neuroscience · 2018Article
- How do horizontal cells 'talk' to cone photoreceptors? Different levels of complexity at the cone-horizontal cell synapse.The Journal of physiology · 2017Review
- Connectomics of synaptic microcircuits: lessons from the outer retina.The Journal of physiology · 2017Review
- Kinetics of Inhibitory Feedback from Horizontal Cells to Photoreceptors: Implications for an Ephaptic Mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo.Nature communications · 2016Article
- Extracellular Cysteine in Connexins: Role as Redox Sensors.Frontiers in physiology · 2016Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the vertebrate retina, cones project to the horizontal cells (HCs) and bipolar cells (BCs). The communication between cones and HCs uses both chemical and ephaptic mechanisms. Cones release glutamate in a Ca(2+)-dependent manner, while HCs feed back to cones via an ephaptic mechanism. Hyperpolarization of HCs leads to an increased current through connexin hemichannels located on the tips of HC dendrites invaginating the cone synaptic terminals. Due to the high resistance of the extracellular synaptic space, this current makes the synaptic cleft slightly negative. The result is that the Ca(2+)-channels in the cone presynaptic membrane experience a slightly depolarized membrane potential and therefore more glutamate is released. This ephaptic mechanism forms a very fast and noise free negative feedback pathway. These characteristics are crucial, since the retina has to perform well in demanding conditions such as low light levels. In this mini-review we will discuss the critical components of such an ephaptic mechanism. Furthermore, we will address the question whether such communication appears in other systems as well and indicate some fundamental features to look for when attempting to identify an ephaptic mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.