SynthesisPLoS genetics2013
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 7 pooled it
6.8field-weighted citation impact, top 3% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
114 citing papers in PubMed, 7 syntheses or guidelines pooled it, 185 citations in OpenAlex.
- Investigating Causal Associations of Circulating Micronutrients Concentrations with the Risk of Lung Cancer: A Mendelian Randomization Study.Nutrients · 2022Pooled it
- Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease.Circulation · 2019Pooled it
- Genetic predisposition to increased serum calcium, bone mineral density, and fracture risk in individuals with normal calcium levels: mendelian randomisation study.BMJ (Clinical research ed.) · 2019Pooled it
- Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.BMJ (Clinical research ed.) · 2018Pooled it
- Genome-wide meta-analysis identifies novel loci associated with parathyroid hormone level.Molecular medicine (Cambridge, Mass.) · 2018Pooled it
- Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.American journal of human genetics · 2018Pooled it
- Pleiotropic genes for metabolic syndrome and inflammation.Molecular genetics and metabolism · 2014Pooled it
- Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank.Circulation. Genomic and precision medicine · 2021Trial
- Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis.PLoS medicine · 2019Trial
- Serum calcium and risk of migraine: a Mendelian randomization study.Human molecular genetics · 2017Trial
- Kidney function decline and kidney stone risk: cohort and Mendelian randomization analyses.Renal failure · 2026Article
- Predictive value of family history of kidney stones for metabolic abnormalities and stone composition.World journal of urology · 2026Article
- Recovering signatures of archaic introgression using ancestral recombination graphs.bioRxiv : the preprint server for biology · 2026Article
- Causal Associations of Circulating Micronutrients With the Risk of Infertility: A Mendelian Randomization Study.Food science & nutrition · 2025Article
- Network Interactions of Circulating FGF23, HRG-HMGB1, and Cardiac Disease in CKD.Journal of the American Society of Nephrology : JASN · 2025Article
- Genetic evidence of the causal relationship between serum micronutrients and Graves' disease: A Mendelian randomization and cross-sectional observational study.Asia Pacific journal of clinical nutrition · 2025Observational
- Mapping the role of macro and micronutrients in bone mineral density: a comprehensive Mendelian randomization study.European journal of nutrition · 2025Article
- Causal Effects of Circulating Micronutrients on Cognitive Function: Evidence From a Mendelian Randomization Study.Brain and behavior · 2025Article
- Genetic Polymorphisms in Cytochrome P450 Enzymes Involved in Vitamin D Metabolism and the Vitamin D Receptor: Their Clinical Relevance.Journal of personalized medicine · 2025Review
- Y chromosome-linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues.Science advances · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
111 authors at 20 institutions in 10 countries.
Conall M O'SeaghdhaNational Heart, Lung, and Blood Institute's Framingham Heart Study and Center for Population Studies, Framingham, Massachusetts, United States of America ; Renal Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Hongsheng Wu
Qiong Yang
Karen Kapur
Idris Guessous
Annie Mercier Zuber
Anna Köttgen
Candice Stoudmann
Alexander Teumer
Zoltán Kutalik
Massimo Mangino
Abbas Dehghan
Weihua Zhang
Gudny Eiriksdottir
Guo Li
Toshiko Tanaka
Laura Portas
Lorna M Lopez
Caroline Hayward
Kurt Lohman
Koichi Matsuda
Sandosh Padmanabhan
Dmitri Firsov
Rossella Sorice
Sheila Ulivi
A Catharina Brockhaus
Marcus E Kleber
Anubha Mahajan
Florian D Ernst
Vilmundur Gudnason
Lenore J Launer
Aurelien Mace
Eric Boerwinckle
Dan E Arking
Chizu Tanikawa
Yusuke Nakamura
Morris J Brown
Jean-Michel Gaspoz
Jean-Marc Theler
David S Siscovick
Bruce M Psaty
Sven Bergmann
Peter Vollenweider
Veronique Vitart
Alan F Wright
Tatijana Zemunik
Mladen Boban
Ivana Kolcic
Pau Navarro
Edward M Brown
Karol Estrada
Jingzhong Ding
Tamara B Harris
Stefania Bandinelli
Dena Hernandez
Andrew B Singleton
Giorgia Girotto
Daniela Ruggiero
Adamo Pio d'Adamo
Antonietta Robino
Thomas Meitinger
Christa Meisinger
Gail Davies
John M Starr
John C Chambers
Bernhard O Boehm
Bernhard R Winkelmann
Jie Huang
Federico Murgia
Sarah H Wild
Harry Campbell
Andrew P Morris
Oscar H Franco
Albert Hofman
Andre G Uitterlinden
Fernando Rivadeneira
Uwe Völker
Anke Hannemann
Reiner Biffar
Wolfgang Hoffmann
So-Youn Shin
Pierre Lescuyer
Hughes Henry
Claudia Schurmann
SUNLIGHT Consortium
GEFOS Consortium
Patricia B Munroe
Paolo Gasparini
Nicola Pirastu
Marina Ciullo
Christian Gieger
Winfried März
Lars Lind
Tim D Spector
Albert V Smith
Igor Rudan
James F Wilson
Ozren Polasek
Ian J Deary
Mario Pirastu
Luigi Ferrucci
Yongmei Liu
Bryan Kestenbaum
Jaspal S Kooner
Jacqueline C M Witteman
Matthias Nauck
W H Linda Kao
Henri Wallaschofski
Olivier Bonny
Caroline S Fox
Murielle Bochud
University of Edinburgh · GBUniversity of Lausanne · CHIRCCS Materno Infantile Burlo Garofolo · ITErasmus MC · NLNational Institute on Aging · USUniversitätsmedizin Greifswald · DEWake Forest University · USUniversität Greifswald · DEUniversity Hospital of Geneva · CHUniversity of Split · HREaling Hospital · GBHelmholtz Zentrum München · DEInstitute of Genetics and Biophysics · ITMRC Institute of Genetics and Molecular Medicine · GBUniversity of Washington · USCentre for Human Genetics · GBIcelandic Heart Association · ISInstitute of Social and Preventive Medicine · CHJohns Hopkins University · USSIB Swiss Institute of Bioinformatics · CH
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MUCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MCHS Events Follow-up StudyR01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2009 to 2014
$6.3MWGA Study to Identify Genetic Variants Associated with CV Events in CHSR01HL087652 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2007 to 2009
$5.1MCHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6MPredictors of Alheimers Disease in Mild Cognitive ImpairmentR01AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2002 to 2011
$3.7MBiotechnology and Biological Sciences Research Council BB/F019394/1Chief Scientist Office CZB/4/710Medical Research Council G0700704Medical Research Council MC_PC_U127561128Medical Research Council MC_PC_U127592696Medical Research Council MC_U127592696Medical Research Council MR/K026992/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NCRR NIH HHS UL1 RR033176NCRR NIH HHS UL1RR033176NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL080295NHLBI NIH HHS HL087652NHLBI NIH HHS HL105756NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC-15103NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS N01-HC-35129NHLBI NIH HHS N01-HC-45133NHLBI NIH HHS N01 HC-55222NHLBI NIH HHS N01- HC-75150NHLBI NIH HHS N01-HC-85079NHLBI NIH HHS N01-HC-85086NHLBI NIH HHS N01-HC- 85239NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL59367NHLBI NIH HHS U01 HL080295NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS AG-023629NIA NIH HHS AG-027058NIA NIH HHS AG-15928NIA NIH HHS AG-20098NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01-AG-1-2100NIA NIH HHS N01AG62101NIA NIH HHS N01AG62103NIA NIH HHS N01AG62106NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG027058NIA NIH HHS R01 AG032098NIA NIH HHS R56 AG020098NIA NIH HHS R56 AG023629NIDDK NIH HHS DK063491NIDDK NIH HHS P30 DK063491NIMHD NIH HHS 263 MD 821336NIMHD NIH HHS 263 MD 9164NIMHD NIH HHS R01 MD009164PHS HHS HHSN268200625226CPHS HHS HSN268201100012CPHS HHS KO3598/2-1Wellcome Trust 064890Wellcome Trust 081682Wellcome Trust 090532Wellcome Trust 098017
Abstract
Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in ≤ 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis.
Indexed as
Genome-Wide Association StudyAnimalsBone and BonesBone DensityCalciumGene Expression RegulationHomeostasisHumansKidneyMicePolymorphism, Single NucleotideWhite PeopleCalcium
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