ArticlePLoS genetics2013
MYB64 and MYB119 are required for cellularization and differentiation during female gametogenesis in Arabidopsis thaliana.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 66 citations in OpenAlex.
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- From gametes to zygote: Mechanistic advances and emerging possibilities in plant reproduction.Plant physiology · 2024Review
- Mutation of DEFECTIVE EMBRYO SAC1 results in a low seed-setting rate in rice by regulating embryo sac development.Journal of experimental botany · 2023Article
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- The type-B response regulators ARR10, ARR12, and ARR18 specify the central cell in Arabidopsis.The Plant cell · 2022Article
- Induction of distinct plant cell death programs by secreted proteins from the wheat pathogen Zymoseptoria tritici.Scientific reports · 2022Article
- Paternal imprinting of dosage-effect defective1 contributes to seed weight xenia in maize.Nature communications · 2022Article
- Early seed development requires the A-type ATP-binding cassette protein ABCA10.Plant physiology · 2022Article
- Evolution and functional diversification of R2R3-MYB transcription factors in plants.Horticulture research · 2022Article
- Spatiotemporal control of miR398 biogenesis, via chromatin remodeling and kinase signaling, ensures proper ovule development.The Plant cell · 2021Article
- Rice MutLγ, the MLH1-MLH3 heterodimer, participates in the formation of type I crossovers and regulation of embryo sac fertility.Plant biotechnology journal · 2021Article
- In Silico Identification of the Complex Interplay between Regulatory SNPs, Transcription Factors, and Their Related Genes inInternational journal of molecular sciences · 2021Article
- The Interaction Network and Signaling Specificity of Two-Component System inInternational journal of molecular sciences · 2020Review
- Comparative Expression Profiling Reveals Genes Involved in Megasporogenesis.Plant physiology · 2020Article
- Transcriptional repression specifies the central cell for double fertilization.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genome-Wide Analysis of the MYB Transcription Factor Superfamily inInternational journal of molecular sciences · 2020Article
- Central Cell in Flowering Plants: Specification, Signaling, and Evolution.Frontiers in plant science · 2020Review
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In angiosperms, the egg cell forms within the multicellular, haploid female gametophyte. Female gametophyte and egg cell development occurs through a unique process in which a haploid spore initially undergoes several rounds of synchronous nuclear divisions without cytokinesis, resulting in a single cell containing multiple nuclei. The developing gametophyte then forms cell walls (cellularization) and the resulting cells differentiate to generate the egg cell and several accessory cells. The switch between free nuclear divisions and cellularization-differentiation occurs during developmental stage FG5 in Arabidopsis, and we refer to it as the FG5 transition. The molecular regulators that initiate the FG5 transition during female gametophyte development are unknown. In this study, we show using mutant analysis that two closely related MYB transcription factors, MYB64 and MYB119, act redundantly to promote this transition. MYB64 and MYB119 are expressed during the FG5 transition, and most myb64 myb119 double mutant gametophytes fail to initiate the FG5 transition, resulting in uncellularized gametophytes with supernumerary nuclei. Analysis of cell-specific markers in myb64 myb119 gametophytes that do cellularize suggests that gametophytic polarity and differentiation are also affected. We also show using multiple-mutant analysis that MYB119 expression is regulated by the histidine kinase CKI1, the primary activator of two-component signaling (TCS) during female gametophyte development. Our data establish a molecular pathway regulating the FG5 transition and implicates CKI1-dependent TCS in the promotion of cellularization, differentiation, and gamete specification during female gametogenesis.
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