ReviewMediators of inflammation2013
Tumor necrosis factor- α and interleukin-6: potential interorgan inflammatory mediators contributing to destructive periodontal disease in obesity or metabolic syndrome.
Review in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02618486 (The Effects of Obesity on Non Surgical Periodontal Therapy), which is not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Obesity on Non Surgical Periodontal Therapy
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Association of mastication and factors affecting masticatory function with obesity in adults: a systematic review.BMC oral health · 2018Pooled it
- Association between obesity and periodontal disease. A systematic review of epidemiological studies and controlled clinical trials.Medicina oral, patologia oral y cirugia bucal · 2017Pooled it
- Change of periodontal inflammatory indicators through a 4-week weight control intervention including caloric restriction and exercise training in young Koreans: a pilot study.BMC oral health · 2015Trial
- Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans.Mediators of inflammation · 2015Trial
- Met@MPDA rejuvenates BMSC energy metabolism to promote bone regeneration in semaglutide-treated obese periodontitis.Materials today. Bio · 2026Article
- Review
- Review
- Central adiposity indices and inflammatory markers mediate the association between life's crucial 9 and periodontitis in US adults.Lipids in health and disease · 2025Article
- The research progress on periodontitis by the National Natural Science Foundation of China.International journal of oral science · 2025Review
- Association between metabolic syndrome and salivary MMP-8, myeloperoxidase in periodontitis.Oral diseases · 2025Article
- Periodontitis Provokes Retinal Neurodegenerative Effects of Metabolic Syndrome: A Cross-Sectional Study.Dentistry journal · 2024Article
- Interlinked Pathways: Exploring the Bidirectional Impacts of Periodontitis and Metabolic Syndrome.Cureus · 2024Review
- Association between weight-adjusted waist index and periodontitis: A population-based study.PloS one · 2024Article
- Periodontal Disease and Its Association with Metabolic Syndrome-A Comprehensive Review.International journal of molecular sciences · 2023Review
- Potential Impact of Prosthetic Biomaterials on the Periodontium: A Comprehensive Review.Molecules (Basel, Switzerland) · 2023Review
- Article
- Efficacy and safety of the integration of traditional Chinese medicine and western medicine in the treatment of diabetes-associated cognitive decline: a systematic review and meta-analysis.Frontiers in pharmacology · 2023Review
- Pediatric obesity-Long-term consequences and effect of weight loss.Journal of internal medicine · 2022Review
- Effects of grape seed proanthocyanidins on the expression of inflammatory mediators in gingival epithelial cells.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Prevalence and Risk Factors for Periodontal Disease Among Women Attending Antenatal Care in Public Hospitals, Southwest Ethiopia, 2022: A Multicenter Cross-Sectional Study.Clinical, cosmetic and investigational dentistry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Obesity has become a worldwide health burden in the last two decades. Obesity has been associated with increased comorbidities, such as coronary artery disease, diabetes, and destructive periodontal disease. Obesity is also part of a group of risk factors occurring together in an individual, which is referred to as metabolic syndrome. Clinical studies have shown higher risk for destructive periodontal disease in obesity and metabolic syndrome. However, the role of obesity and metabolic syndrome in the onset and development of destructive periodontal disease has not yet been fully understood. In this review, we discuss a working model, which focuses on interorgan inflammation as a common etiological factor for destructive periodontal disease associated with obesity and metabolic syndrome. Specifically, we suggest that elevated levels of tumor necrosis factor- α (TNF- α ) or interleukin 6 (IL-6)--both adipokines and known risk factors for destructive periodontal disease--in obesity and metabolic syndrome contribute to the onset and development of destructive periodontal disease. The connections between destructive periodontal disease and systemic conditions, such as obesity or metabolic syndrome, are complex and potentially multidirectional. This review largely focuses on TNF- α and IL-6, inflammatory mediators, as potential common risk factors and does not exclude other biological mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.