ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Cytoarchitectonic and dynamic origins of giant positive local field potentials in the dentate gyrus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Dentate spikes comprise a continuum of relative input strength from the lateral and medial entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
- Toothy: an interactive platform for dentate spike curation.bioRxiv : the preprint server for biology · 2025Article
- Brain sources composing irregular field potentials have unique temporal signatures.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Intracranial Voltage Profiles from Untangled Human Deep Sources Reveal Multisource Composition and Source Allocation Bias.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Wireless system for recording evoked potentials.The journal of physiological sciences : JPS · 2024Article
- Identification of Early Hippocampal Dynamics during Recognition Memory with Independent Component Analysis.eNeuro · 2024Article
- Site-dependent shaping of field potential waveforms.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Uncorrelated bilateral cortical input becomes timed across hippocampal subfields for long waves whereas gamma waves are largely ipsilateral.Frontiers in cellular neuroscience · 2023Article
- Theoretical considerations and supporting evidence for the primary role of source geometry on field potential amplitude and spatial extent.Frontiers in cellular neuroscience · 2023Review
- Neuroligin-3 Regulates Excitatory Synaptic Transmission and EPSP-Spike Coupling in the Dentate Gyrus In Vivo.Molecular neurobiology · 2022Article
- Dentate spikes and external control of hippocampal function.Cell reports · 2021Article
- Gamma rhythm communication between entorhinal cortex and dentate gyrus neuronal assemblies.Science (New York, N.Y.) · 2021Article
- Article
- Mechanisms of the negative potential associated with Leão's spreading depolarization: A history of brain electrogenesis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Review
- Probing regional cortical excitability via input-output properties using transcranial magnetic stimulation and electroencephalography coupling.Human brain mapping · 2020Article
- Admittance Method for Estimating Local Field Potentials Generated in a Multi-Scale Neuron Model of the Hippocampus.Frontiers in computational neuroscience · 2020Article
- Slow-Wave Activity in the S1HL Cortex Is Contributed by Different Layer-Specific Field Potential Sources during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Volume-Conducted Origin of the Field Potential at the Lateral Habenula.Frontiers in systems neuroscience · 2019Article
- Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation.Nature neuroscience · 2018Review
- Hippocampal Network Dynamics during Rearing Episodes.Cell reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine why some pathways but not others produce sizable local field potentials (LFPs) and how far from the source can these be recorded, complementary experimental analyses and realistic modeling of specific brain structures are required. In the present study, we combined multiple in vivo linear recordings in rats and a tridimensional finite element model of the dentate gyrus, a curved structure displaying abnormally large positive LFPs. We demonstrate that the polarized dendritic arbour of granule cells (GCs), combined with the curved layered configuration of the population promote the spatial clustering of GC currents in the interposed hilus and project them through the open side at a distance from cell domains. LFPs grow up to 20 times larger than observed in synaptic sites. The dominant positive polarity of hilar LFPs was only produced by the synchronous activation of GCs in both blades by either somatic inhibition or dendritic excitation. Moreover, the corresponding anatomical pathways must project to both blades of the dentate gyrus as even a mild decrease in the spatial synchronization resulted in a dramatic reduction in LFP power in distant sites, yet not in the GC domains. It is concluded that the activation of layered structures may establish sharply delimited spatial domains where synaptic currents from one or another input appear to be segregated according to the topology of afferent pathways and the cytoarchitectonic features of the target population. These also determine preferred directions for volume conduction in the brain, of relevance for interpretation of surface EEG recordings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.