ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Activation of presynaptic GABA(B(1a,2)) receptors inhibits synaptic transmission at mammalian inhibitory cholinergic olivocochlear-hair cell synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Neurexin regulates mechanical nociceptive sensitization by central inhibition inScience advances · 2025Article
- Co-release of GABA and ACh from Medial Olivocochlear Neurons as a Fine Regulatory Mechanism of Cochlear Efferent Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- GABAergic synapses between auditory efferent neurons and type II spiral ganglion afferent neurons in the mouse cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Co-release of GABA and ACh from medial olivocochlear neurons fine tunes cochlear efferent inhibition.bioRxiv : the preprint server for biology · 2024Article
- Fast Inhibition Slows and Desynchronizes Mouse Auditory Efferent Neuron Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The role of GABAFrontiers in endocrinology · 2023Review
- Diverse identities and sites of action of cochlear neurotransmitters.Hearing research · 2022Review
- G protein-coupled receptors in cochlea: Potential therapeutic targets for hearing loss.Frontiers in molecular neuroscience · 2022Review
- Putative COVID-19 therapies imatinib, lopinavir, ritonavir, and ivermectin cause hair cell damage: A targeted screen in the zebrafish lateral line.Frontiers in cellular neuroscience · 2022Article
- Functional P2XThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Nicotine evoked efferent transmitter release onto immature cochlear inner hair cells.Journal of neurophysiology · 2020Article
- Activation of GABAJournal of neurophysiology · 2020Article
- Cochlear protein biomarkers as potential sites for targeted inner ear drug delivery.Drug delivery and translational research · 2020Review
- Developmental Synaptic Changes at the Transient Olivocochlear-Inner Hair Cell Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Efferent Inhibition of the Cochlea.Cold Spring Harbor perspectives in medicine · 2019Review
- Enhancement of the Medial Olivocochlear System Prevents Hidden Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Voltage-Gated Calcium Influx Modifies Cholinergic Inhibition of Inner Hair Cells in the Immature Rat Cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- A Gain-of-Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short-Term Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Muscarinic acetylcholine receptors control baseline activity and Hebbian stimulus timing-dependent plasticity in fusiform cells of the dorsal cochlear nucleus.Journal of neurophysiology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
The synapse between olivocochlear (OC) neurons and cochlear mechanosensory hair cells is cholinergic, fast, and inhibitory. The inhibitory sign of this cholinergic synapse is accounted for by the activation of Ca(2+)-permeable postsynaptic α9α10 nicotinic receptors coupled to the opening of hyperpolarizing Ca(2+)-activated small-conductance type 2 (SK2)K(+) channels. Acetylcholine (ACh) release at this synapse is supported by both P/Q- and N-type voltage-gated calcium channels (VGCCs). Although the OC synapse is cholinergic, an abundant OC GABA innervation is present along the mammalian cochlea. The role of this neurotransmitter at the OC efferent innervation, however, is for the most part unknown. We show that GABA fails to evoke fast postsynaptic inhibitory currents in apical developing inner and outer hair cells. However, electrical stimulation of OC efferent fibers activates presynaptic GABA(B(1a,2)) receptors [GABA(B(1a,2))Rs] that downregulate the amount of ACh released at the OC-hair cell synapse, by inhibiting P/Q-type VGCCs. We confirmed the expression of GABA(B)Rs at OC terminals contacting the hair cells by coimmunostaining for GFP and synaptophysin in transgenic mice expressing GABA(B1)-GFP fusion proteins. Moreover, coimmunostaining with antibodies against the GABA synthetic enzyme glutamic acid decarboxylase and synaptophysin support the idea that GABA is directly synthesized at OC terminals contacting the hair cells during development. Thus, we demonstrate for the first time a physiological role for GABA in cochlear synaptic function. In addition, our data suggest that the GABA(B1a) isoform selectively inhibits release at efferent cholinergic synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.