ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Decrease of gray matter volume in the midbrain is associated with treatment response in medication-overuse headache: possible influence of orbitofrontal cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Imaging the brain and vascular reactions to headache treatments: a systematic review.The journal of headache and pain · 2023Pooled it
- Gray matter alteration in medication overuse headache: a coordinates-based activation likelihood estimation meta-analysis.Brain imaging and behavior · 2022Pooled it
- Grey matter alterations in migraine: A systematic review and meta-analysis.NeuroImage. Clinical · 2017Pooled it
- Breaking the medication overuse headache cycle: from nociplastic pain mechanisms to patient-centered interventions - the Junior Editorial Board vision.The journal of headache and pain · 2026Review
- Advances of neuroimaging findings in medication overuse headache.Frontiers in neuroscience · 2025Review
- Neurobehavioral features in medication-overuse headache.eNeurologicalSci · 2024Article
- Hypoperfusion of hypothalamic subunits in medication-overuse headache using a 3D PCASL MRI.Scientific reports · 2024Article
- Medication-overuse headache: a narrative review.The journal of headache and pain · 2024Review
- A Descriptive Review of Medication-Overuse Headache: From Pathophysiology to the Comorbidities.Brain sciences · 2023Review
- Medication overuse headache and substance use disorder: A comparison based on basic research and neuroimaging.Frontiers in neurology · 2023Review
- Functional connectivity of the visual cortex in chronic migraine before and after medication withdrawal therapy.NeuroImage. Clinical · 2023Article
- Cortical metabolic and structural differences in patients with chronic migraine. An exploratoryThe journal of headache and pain · 2021Article
- Evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients: a diffusion tensor imaging study.Arquivos de neuro-psiquiatria · 2021Article
- Altered local and distant functional connectivity density in chronic migraine: a resting-state functional MRI study.Neuroradiology · 2021Article
- Migraine Is More Than Just Headache: Is the Link to Chronic Fatigue and Mood Disorders Simply Due to Shared Biological Systems?Frontiers in human neuroscience · 2021Review
- Chronic Migraine Pathophysiology and Treatment: A Review of Current Perspectives.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
- Voxel-Based Morphometry-from Hype to Hope. A Study on Hippocampal Atrophy in Mesial Temporal Lobe Epilepsy.AJNR. American journal of neuroradiology · 2020Article
- Cortical pain processing in migraine.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Medication Overuse Withdrawal in Children and Adolescents Does Not Always Improve Headache: A Cross-Sectional Study.Frontiers in neurology · 2020Article
- Withdrawal from acute medication normalises short-term cortical synaptic potentiation in medication overuse headache.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with chronic daily headache and overuse of analgesics, triptans, or other acute headache compounds, are considered to suffer from medication-overuse headache (MOH). This implies that medication overuse is the cause of headache chronification. It remains a key question why only two-thirds of patients with chronic migraine-like headache and overuse of pain medication improve after detoxification, whereas the remainder continue to have chronic headache. In the present longitudinal MRI study, we used voxel-based morphometry to investigate gray matter changes related to medication withdrawal in a group of humans with MOH. As a main result, we found that only patients with significant clinical improvement showed a significant decrease of previously increased gray matter in the midbrain including periaqueductal gray matter and nucleus cuneiformis, whereas patients without improvement did not. Patients without treatment response had less gray matter in the orbitofrontal cortex. Another striking result is the correlation of treatment response with the amount of orbitofrontal gray matter. Thus, we demonstrate adaptive gray matter changes within the pain modulatory system in patients with MOH who responded to detoxification, probably reflecting neuronal plasticity. Decreased gray matter in the orbitofrontal cortex at baseline may be predictive of poor response to treatment.
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