ArticleGenome biology and evolution2013
Female and male gamete mitochondria are distinct and complementary in transcription, structure, and genome function.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 47 citations in OpenAlex.
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- Mitochondrial DNA Damage and Its Repair Mechanisms in Aging Oocytes.International journal of molecular sciences · 2024Review
- Spatiotemporal Distribution and Function of Mitochondria in Oocytes.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Role of insulin-like growth factor 1 (IGF1) in the regulation of mitochondrial bioenergetics in zebrafish oocytes: lessons fromFrontiers in cell and developmental biology · 2023Article
- Social networks in the single cell.Journal of experimental botany · 2022Article
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- Mitochondrial proteome of mouse oocytes and cisplatin-induced shifts in protein profile.Acta pharmacologica Sinica · 2021Article
- A sex chromosome inversion is associated with copy number variation of mitochondrial DNA in zebra finch sperm.Royal Society open science · 2021Article
- Bioenergetic consequences of sex-specific mitochondrial DNA evolution.Proceedings. Biological sciences · 2021Article
- Cytoplasmic maturation in human oocytes: an ultrastructural study †.Biology of reproduction · 2021Article
- Review
- Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase inAntioxidants (Basel, Switzerland) · 2020Article
- DNA Repair and the Stability of the Plant Mitochondrial Genome.International journal of molecular sciences · 2020Review
- The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness.Proceedings. Biological sciences · 2019Article
- Mitochondria: the panacea to improve oocyte quality?Annals of translational medicine · 2019Review
- A battle for transmission: the cooperative and selfish animal mitochondrial genomes.Open biology · 2019Review
- Sex and Mitonuclear Adaptation in ExperimentalGenetics · 2019Article
- Iron Sulfur and Molybdenum Cofactor Enzymes Regulate theFrontiers in physiology · 2018Article
- Single-sperm sequencing reveals the accelerated mitochondrial mutation rate in maleProceedings. Biological sciences · 2017Article
- Mitochondrial membrane potential: a trait involved in organelle inheritance?Biology letters · 2015Article
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7 authors at 6 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Respiratory electron transport in mitochondria is coupled to ATP synthesis while generating mutagenic oxygen free radicals. Mitochondrial DNA mutation then accumulates with age, and may set a limit to the lifespan of individual, multicellular organisms. Why is this mutation not inherited? Here we demonstrate that female gametes-oocytes-have unusually small and simple mitochondria that are suppressed for DNA transcription, electron transport, and free radical production. By contrast, male gametes-sperm-and somatic cells of both sexes transcribe mitochondrial genes for respiratory electron carriers and produce oxygen free radicals. This germ-line division between mitochondria of sperm and egg is observed in both the vinegar fruitfly and the zebrafish-species spanning a major evolutionary divide within the animal kingdom. We interpret these findings as an evidence that oocyte mitochondria serve primarily as genetic templates, giving rise, irreversibly and in each new generation, to the familiar energy-transducing mitochondria of somatic cells and male gametes. Suppressed mitochondrial metabolism in the female germ line may therefore constitute a mechanism for increasing the fidelity of mitochondrial DNA inheritance.
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