ArticleEuropean journal of applied physiology2013
A single bout of downhill running transiently increases HOMA-IR without altering adipokine response in healthy adult women.
Article in European journal of applied physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06417671 (The Effect of Postbiotics Supplementation on Exercise-induced Oxidative Stress.), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Postbiotics Supplementation on Exercise-induced Oxidative Stress.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The Effect of Eccentric vs. Traditional Resistance Exercise on Muscle Strength, Body Composition, and Functional Performance in Older Adults: A Systematic Review With Meta-Analysis.Frontiers in sports and active living · 2022Pooled it
- Effect of cold-water immersion treatment on recovery from exercise-induced muscle damage in the hamstring.European journal of sport science · 2025Trial
- Cytokine, glycemic, and insulinemic responses to an acute bout of games-based activity in adolescents.Scandinavian journal of medicine & science in sports · 2019Trial
- Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children.Oxidative medicine and cellular longevity · 2017Trial
- Effect of resistance training on muscular strength and indicators of abdominal adiposity, metabolic risk, and inflammation in postmenopausal women: controlled and randomized clinical trial of efficacy of training volume.Age (Dordrecht, Netherlands) · 2016Trial
- Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Observational
- Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance.Scientific reports · 2021Article
- Downhill Running: What Are The Effects and How Can We Adapt? A Narrative Review.Sports medicine (Auckland, N.Z.) · 2020Review
- Acute responses of bone specific and related markers to maximal eccentric exercise of the knee extensors and flexors in young men.Journal of musculoskeletal & neuronal interactions · 2020Article
- Irisin response to downhill running exercise in humans.Journal of exercise nutrition & biochemistry · 2018Article
- Chronic Eccentric Exercise and Antioxidant Supplementation: Effects on Lipid Profile and Insulin Sensitivity.Journal of sports science & medicine · 2017Article
- Superior Effects of Eccentric to Concentric Knee Extensor Resistance Training on Physical Fitness, Insulin Sensitivity and Lipid Profiles of Elderly Men.Frontiers in physiology · 2017Article
- Fatigue associated with prolonged graded running.European journal of applied physiology · 2016Review
- Does achilles tendon cross sectional area differ after downhill, level and uphill running in trained runners?Journal of sports science & medicine · 2014Article
- Effects of Acute Eccentric Exercise on Appetite-Related Hormones and Food Preferences in Men.American journal of men's healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEccentric exercise-induced muscle damage may cause marked alterations in insulin sensitivity. However, it is not entirely known whether such alterations are also related to changes in adipokine levels. The aim of this study was to investigate the effects of muscle damage due to downhill running on inflammation, insulin sensitivity and selected adipokines related to insulin regulation (adiponectin, visfatin, resistin).
methodsData were collected from 12 healthy adult women. Each subject participated in two trials, 4 weeks apart. The first trial was reserved for resting measurements only (control trial), while the second trial involved a 45-min exercise (-15 % slope, ~60 % of VO2max) intervention (exercise trial). Insulin sensitivity (HOMA), creatine kinase activity (CK), delayed onset muscle soreness (DOMS), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), glucose, insulin, adiponectin, resistin, and visfatin were assessed pre-exercise and 1, 2, 3, and 4 days post-exercise and during the same time points in the control trial.
resultsAnalyses revealed that CK, DOMS, TNF-α, IL-6, insulin and HOMA significantly increased (p < 0.05) throughout recovery (days 1-4). Adiponectin and visfatin remained unchanged, while resistin significantly increased (p < 0.05) only 2 days post-exercise. Visfatin was negatively correlated with HOMA at days 1 and 4 of recovery.
conclusionAlthough muscle damage due to downhill running caused a decline of insulin sensitivity, this response was not associated with the changes in adipokine levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.