ArticleAmerican journal of epidemiology2013
Levels of cotinine in dried blood specimens from newborns as a biomarker of maternal smoking close to the time of delivery.
Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Environmental tobacco smoke and carotid intima-media thickness in healthy children and adolescents: a systematic review.Open heart · 2022Pooled it
- Pooled it
- An untargeted metabolome-wide association study of maternal perinatal tobacco smoking in newborn blood spots.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- A Prospective Analysis of Per- and Polyfluoroalkyl Substances from Early Pregnancy to Delivery in the Atlanta African American Maternal-Child Cohort.Environmental health perspectives · 2024Article
- A prediction model for classifying maternal pregnancy smoking using California state birth certificate information.Paediatric and perinatal epidemiology · 2024Article
- Metabolite Stability in Archived Neonatal Dried Blood Spots Used for Epidemiologic Research.American journal of epidemiology · 2023Article
- A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots.Journal of exposure science & environmental epidemiology · 2023Review
- Child serum metabolome and traffic-related air pollution exposure in pregnancy.Environmental research · 2022Article
- Using primary teeth and archived dried spots for exposomic studies in children: Exploring new paths in the environmental epidemiology of pediatric cancer.BioEssays : news and reviews in molecular, cellular and developmental biology · 2021Review
- Nicotine and Its Downstream Metabolites in Maternal and Cord Sera: Biomarkers of Prenatal Smoking Exposure Associated with Offspring DNA Methylation.International journal of environmental research and public health · 2020Article
- Little to Give, Much to Gain-What Can You Do With a Dried Blood Spot?Current environmental health reports · 2020Review
- Untargeted adductomics of Cys34 modifications to human serum albumin in newborn dried blood spots.Analytical and bioanalytical chemistry · 2019Article
- Biomarkers of Exposure to Secondhand and Thirdhand Tobacco Smoke: Recent Advances and Future Perspectives.International journal of environmental research and public health · 2018Review
- Eliciting parental support for the use of newborn blood spots for pediatric research.BMC medical research methodology · 2016Article
- Juvenile idiopathic arthritis in relation to maternal prenatal smoking.Arthritis care & research · 2015Article
- Accuracy of prenatal smoking data from Washington State birth certificates in a population-based sample with cotinine measurements.Annals of epidemiology · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The precise quantitation of smoking during pregnancy is difficult in retrospective studies. Routinely collected blood specimens from newborns, stored as dried blood spots, may provide a low-cost method to objectively measure maternal smoking close to the time of delivery. This article compares cotinine levels in dried blood spots to those in umbilical cord blood to assess cotinine in dried blood spots as a biomarker of maternal smoking close to the time of delivery. The California Genetic Disease Screening Program provided dried blood spots from 428 newborns delivered in 2001-2003 with known umbilical cord blood cotinine levels. Cotinine in dried blood spots was measured in 6.35--mm punches by using liquid chromatography--tandem mass spectrometry (quantitation limit, 3.1 ng/mL). Repeated measures of cotinine in dried blood spots were highly correlated (R(2) = 0.99, P < 0.001) among 100 dried blood spots with cotinine quantitated in 2 separate punches. Linear regression revealed that cotinine levels in dried blood spots were slightly lower than those in umbilical cord blood and predicted umbilical cord blood cotinine levels well (β = 0.95, R(2) = 0.80, and P < 0.001 for both cotinine levels in log10 scale). When defining active smoking as a cotinine level of 10 ng/mL or more and using umbilical cord blood cotinine as the criterion standard, we found that measurements of cotinine in dried blood spots had high sensitivity (92.3%) and specificity (99.7%) in the prediction of maternal active smoking. Cotinine levels in dried blood spots are an accurate biomarker of maternal smoking close to the time of delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.