ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
Ascorbate infusion increases skeletal muscle fatigue resistance in patients with chronic obstructive pulmonary disease.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports.BMC pulmonary medicine · 2024Pooled it
- Capsaicin and Its Effect on Exercise Performance, Fatigue and Inflammation after Exercise.Nutrients · 2022Trial
- Low vitamin C values are linked with decreased physical performance and increased oxidative stress: reversal by vitamin C supplementation.European journal of nutrition · 2016Trial
- Mitochondrial and Epigenetic Drivers of Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease.Antioxidants (Basel, Switzerland) · 2026Review
- Oxidative stress suppresses internal carotid artery dilation to hypercapnia in healthy older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Skeletal muscle mitochondrial adaptations induced by long-term cigarette smoke exposure.American journal of physiology. Endocrinology and metabolism · 2021Article
- Ascorbate attenuates cycling exercise-induced neuromuscular fatigue but fails to improve exertional dyspnea and exercise tolerance in COPD.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Nutritional status and muscle dysfunction in chronic respiratory diseases: stable phase versus acute exacerbations.Journal of thoracic disease · 2018Review
- Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation.American journal of physiology. Heart and circulatory physiology · 2018Article
- Oxygen delivery and the restoration of the muscle energetic balance following exercise: implications for delayed muscle recovery in patients with COPD.American journal of physiology. Endocrinology and metabolism · 2017Article
- Reduced HDAC2 in skeletal muscle of COPD patients.Respiratory research · 2017Article
- Exercise performance and physiological responses: the potential role of redox imbalance.Physiological reports · 2017Article
- Clinical management of chronic obstructive pulmonary disease patients with muscle dysfunction.Journal of thoracic disease · 2016Review
- Article
- Coadministration of Resveratrol and Rice Oil Mitigates Nociception and Oxidative State in a Mouse Fibromyalgia-Like Model.Pain research and treatment · 2016Article
- Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia-Reperfusion Injury.Nutrition and metabolic insights · 2016Article
- Reliability of a Novel High Intensity One Leg Dynamic Exercise Protocol to Measure Muscle Endurance.PloS one · 2016Article
- Quadriceps exercise intolerance in patients with chronic obstructive pulmonary disease: the potential role of altered skeletal muscle mitochondrial respiration.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Oral antioxidants improve leg blood flow during exercise in patients with chronic obstructive pulmonary disease.American journal of physiology. Heart and circulatory physiology · 2015Article
- COPD: balancing oxidants and antioxidants.International journal of chronic obstructive pulmonary disease · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic obstructive pulmonary disease (COPD) is associated with systemic oxidative stress and skeletal muscle dysfunction. The purpose of this study was to examine the impact of intravenous ascorbate administration (AO) on biological markers of antioxidant capacity and oxidative stress, and subsequently skeletal muscle function during dynamic, small muscle mass exercise in patients with COPD. Ten patients with spirometric evidence of COPD performed single-leg knee extensor (KE) trials matched for intensity and time (isotime) following intravenous ascorbate (2 g) or saline infusion (PL). Quadriceps fatigue was quantified by changes in force elicited by maximal voluntary contraction (MVC) and magnetic femoral nerve stimulation (Qtw,pot). AO administration significantly increased antioxidant capacity, as measured by the ferric-reducing ability of plasma (PL: 1 ± 0.1 vs. AO: 5 ± 0.2 mM), and significantly reduced malondialdehyde levels (PL: 1.16 ± 0.1 vs. AO: 0.97 ± 0.1 mmol). Additionally, resting blood pressure was significantly reduced (PL: 104 ± 4 vs. AO: 93 ± 6 mmHg) and resting femoral vascular conductance was significantly elevated after AO (PL: 2.4 ± 0.2 vs. AO: 3.6 ± 0.4 ml·min(-1)·mmHg(-1)). During isotime exercise, the AO significantly attenuated both the ventilatory and metabolic responses, and patients accumulated significantly less peripheral quadriceps fatigue, as illustrated by less of a fall in MVC (PL: -11 ± 2% vs. AO: -5 ± 1%) and Qtw,pot (PL: -37 ± 1% vs. AO: -30 ± 2%). These data demonstrate a beneficial role of AO administration on skeletal muscle fatigue in patients with COPD and further implicate systemic oxidative stress as a causative factor in the skeletal muscle dysfunction observed in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.