ArticleJournal of virology2013
The L gene of J paramyxovirus plays a critical role in viral pathogenesis.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Development of a J paramyxovirus-based vaccine vector.NPJ vaccines · 2026Article
- Article
- Discovery and characterization of novel jeilongviruses in wild rodents from Hubei, China.Virology journal · 2024Article
- Cleavage of the syncytial protein of J paramyxovirus is required for its ability to promote cell-cell fusion.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Evolution and ecology of Jeilongvirus among wild rodents and shrews in Singapore.One health outlook · 2023Article
- Regulation of host gene expression by J paramyxovirus.PloS one · 2023Article
- Genetic Diversity and Expanded Host Range of J Paramyxovirus Detected in Wild Small Mammals in China.Viruses · 2022Article
- Evolution and Diversity of Bat and Rodent Paramyxoviruses from North America.Journal of virology · 2022Article
- Evaluation of a New Viral Vaccine Vector in Mice and Rhesus Macaques: J Paramyxovirus Expressing Hemagglutinin of Influenza A Virus H5N1.Journal of virology · 2021Article
- A novel mutation tolerant padlock probe design for multiplexed detection of hypervariable RNA viruses.Scientific reports · 2019Article
- Role of Small Hydrophobic Protein of J Paramyxovirus in Virulence.Journal of virology · 2018Article
- Type II integral membrane protein, TM of J paramyxovirus promotes cell-to-cell fusion.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
J paramyxovirus (JPV) was first isolated from moribund mice with hemorrhagic lung lesions in Australia in the 1970s. Recent sequencing of JPV (JPV-LW) confirms that JPV is a paramyxovirus with several unique features. However, neither JPV-LW nor a recombinant JPV based on its sequence (rJPV-LW) caused obvious illness in mice. In this work, we analyzed a different JPV isolate (JPV-BH), which behaved differently from JPV-LW; JPV-BH grew more slowly in Vero cells and had less of a cytopathic effect on tissue culture cells but caused severe disease in mice. We have determined the whole genome sequence of JPV-BH. There were several nucleotide sequence differences between JPV-BH and JPV-LW, one in the leader sequence, one in the GX gene, and three in the L gene. The high sequence identity between JPV-BH and JPV-LW suggests that JPV-BH and JPV-LW are the same virus strain but were obtained at different passages from different laboratories. To understand the roles of these nucleotide sequence differences in pathogenicity in mice, we generated a recombinant JPV-BH strain (rJPV-BH) and hybrid rJPV-BH strains with sequences from the leader sequence (rJPV-BH-Le-LW), the GX gene (rJPV-BH-GX-LW), and the L gene (rJPV-BH-L-LW) of JPV-LW and compared their pathogenicities in mice. We have found that rJPV-BH-L-LW was attenuated in mice, indicating that nucleotide sequence differences in the L gene play a critical role in pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.