ArticleProceedings of the National Academy of Sciences of the United States of America2013
Optimizing water permeability through the hourglass shape of aquaporins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 240 citations in OpenAlex.
- When is nanoconfined water different from interfacial water?Faraday discussions · 2026Article
- Covalent organic framework membrane with hourglass-shaped nanochannels for ultrafast desalination.Nature communications · 2025Article
- Aquaporin-1 and Osmosis: From Physiology to Precision in Peritoneal Dialysis.Journal of the American Society of Nephrology : JASN · 2024Review
- Peroxiporins in Triple-Negative Breast Cancer: Biomarker Potential and Therapeutic Perspectives.International journal of molecular sciences · 2024Review
- Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow.Current opinion in cell biology · 2024Review
- Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow.bioRxiv : the preprint server for biology · 2024Article
- Effect of heat stress on the hypothalamic expression profile of water homeostasis-associated genes in low- and high-water efficient chicken lines.Physiological reports · 2024Article
- Structural heterogeneity of the ion and lipid channel TMEM16F.Nature communications · 2024Article
- Mechanosensitive aquaporins.Biophysical reviews · 2023Review
- Tutorial for Stopped-Flow Water Flux Measurements: Why a Report about "Ultrafast Water Permeation through Nanochannels with a Densely Fluorous Interior Surface" Is Flawed.Biomolecules · 2023Article
- Comparison of water desalination performance of porous graphene and MoSRSC advances · 2022Article
- Viscous peeling of a nanosheet.Soft matter · 2022Article
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- Single-layer membranes for organic solvent nanofiltration: a molecular dynamics simulation and comparative experimental study.RSC advances · 2022Article
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- Experimental and Theoretical Analysis of Metal Complex Diffusion through Cell Monolayer.Entropy (Basel, Switzerland) · 2021Article
- Water in Nanopores and Biological Channels: A Molecular Simulation Perspective.Chemical reviews · 2020Review
- Vapor-deposited functional polymer thin films in biological applications.Journal of materials chemistry. B · 2020Review
- Determination of the Membrane Transport Properties of Jurkat Cells with a Microfluidic Device.Micromachines · 2019Article
- Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ubiquitous aquaporin channels are able to conduct water across cell membranes, combining the seemingly antagonist functions of a very high selectivity with a remarkable permeability. Whereas molecular details are obvious keys to perform these tasks, the overall efficiency of transport in such nanopores is also strongly limited by viscous dissipation arising at the connection between the nanoconstriction and the nearby bulk reservoirs. In this contribution, we focus on these so-called entrance effects and specifically examine whether the characteristic hourglass shape of aquaporins may arise from a geometrical optimum for such hydrodynamic dissipation. Using a combination of finite-element calculations and analytical modeling, we show that conical entrances with suitable opening angle can indeed provide a large increase of the overall channel permeability. Moreover, the optimal opening angles that maximize the permeability are found to compare well with the angles measured in a large variety of aquaporins. This suggests that the hourglass shape of aquaporins could be the result of a natural selection process toward optimal hydrodynamic transport. Finally, in a biomimetic perspective, these results provide guidelines to design artificial nanopores with optimal performances.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.