ArticleNature2013
Temperature-dependent regulation of flowering by antagonistic FLM variants.
Article in Nature, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers.
What it found
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Who cites it
228 citing papers in PubMed.
- Changes in Alternative Splicing are Associated with Insecticide Response and Resistance.Genome biology and evolution · 2026Article
- Local Trade-Offs Shape Flower Size Evolution Across Arabidopsis thaliana Distribution.Molecular ecology · 2026Article
- Molecular integration of seasonal temperature signals in flowering time control.Nature reviews. Genetics · 2026Review
- The SVP-FRO6 Module Integrates the Control of Leaf Senescence and Flowering in Arabidopsis.Plant, cell & environment · 2026Article
- Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Review
- Transcriptomic Analysis Provides Insights into Flowering in Precocious-FruitingPlants (Basel, Switzerland) · 2026Article
- Epigenetic Regulation of Floral Transition.Plants (Basel, Switzerland) · 2025Review
- Seasons and shape: inflorescences from autumn to summer.Journal of experimental botany · 2025Review
- STALARD: Selective Target Amplification for Low-Abundance RNA Detection.Plant methods · 2025Article
- Phytochrome B and phytochrome-interacting-factor4 modulate tree seasonal growth in cold environments.Nature communications · 2025Article
- Characterization of FLOWERING LOCUS T-related genes and their putative gene regulatory network in semi-winter Brassica napus cultivar Zhongshaung11.The Plant journal : for cell and molecular biology · 2025Article
- Alternative splicing-mediated regulation of a novel allele of Badh2 drives moderate accumulation of 2-AP in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Canalization of flower production across thermal environments requires Florigen and CLAVATA signaling.Current biology : CB · 2025Article
- High-temperature-induced FKF1 accumulation promotes flowering through the dispersion of GI and degradation of SVP.Nature plants · 2025Article
- Exploring the multifaceted dynamics of flowering time regulation in field crops: Insight and intervention approaches.The plant genome · 2025Review
- Mutations in the floral regulator gene HUA2 restore flowering to the Arabidopsis trehalose 6-phosphate synthase1 (tps1) mutant.Plant physiology · 2025Article
- UV-B Irradiation Does Not Promote Flowering inPlant direct · 2025Article
- ROOT INITIATION DEFECTIVE 1 regulates seed germination through transcription rather than alternative splicing in a temperature-dependent manner.Plant molecular biology · 2025Article
- The CRY1-COP1-HY5 axis mediates blue-light regulation of Arabidopsis thermotolerance.Plant communications · 2025Article
168 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The appropriate timing of flowering is crucial for plant reproductive success. It is therefore not surprising that intricate genetic networks have evolved to perceive and integrate both endogenous and environmental signals, such as carbohydrate and hormonal status, photoperiod and temperature. In contrast to our detailed understanding of the vernalization pathway, little is known about how flowering time is controlled in response to changes in the ambient growth temperature. In Arabidopsis thaliana, the MADS-box transcription factor genes FLOWERING LOCUS M (FLM) and SHORT VEGETATIVE PHASE (SVP) have key roles in this process. FLM is subject to temperature-dependent alternative splicing. Here we report that the two main FLM protein splice variants, FLM-β and FLM-δ, compete for interaction with the floral repressor SVP. The SVP-FLM-β complex is predominately formed at low temperatures and prevents precocious flowering. By contrast, the competing SVP-FLM-δ complex is impaired in DNA binding and acts as a dominant-negative activator of flowering at higher temperatures. Our results show a new mechanism that controls the timing of the floral transition in response to changes in ambient temperature. A better understanding of how temperature controls the molecular mechanisms of flowering will be important to cope with current changes in global climate.
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Registered trials
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