ReviewVirulence2014
Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock.
Review in Virulence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02558166 (Relation Between the Renal Resistive Index and Markers of the Systemic Circulation, the Microcirculation, Fluid Status and of Renal Function.), which is not on this map. Cited by 188 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relation Between the Renal Resistive Index and Markers of the Systemic Circulation, the Microcirculation, Fluid Status and of Renal Function.
Who cites it
188 citing papers in PubMed, 2 syntheses or guidelines pooled it, 367 citations in OpenAlex.
- Peripheral fractional oxygen extraction measured with near-infrared spectroscopy in neonates-A systematic qualitative review.Frontiers in pediatrics · 2022Pooled it
- [Association between peripheral perfusion, microcirculation and mortality in sepsis: a systematic review].Brazilian journal of anesthesiology (Elsevier)Pooled it
- Impact of Oxygen Targets on Sepsis Outcome: A Randomized Controlled Trial.Shock (Augusta, Ga.) · 2026Trial
- Intraoperative intravenous infusion of lidocaine increases total and small vessel densities of sublingual microcirculation: a randomized prospective pilot study.The Journal of international medical research · 2023Trial
- Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis.Cytokine · 2016Trial
- Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock: a randomized, double-blind, placebo-controlled, pilot trial.Critical care (London, England) · 2015Trial
- Sepsis-associated endothelial dysfunction: clinical phenotypes, biomarkers, bedside evidence, and translational implications.The Journal of clinical investigation · 2026Review
- Effect of vasopressin and its analogues on microcirculatory perfusion: a systematic review.Intensive care medicine experimental · 2026Review
- Venous dimension of shock: Integrating arterial inflow and venous back-pressure in hemodynamic assessment.World journal of critical care medicine · 2026Review
- Characterizing the molecular landscape of venous congestion.World journal of critical care medicine · 2026Article
- Risk factors associated with treatment failure in peritoneal dialysis-associated peritonitis.Experimental and therapeutic medicine · 2026Article
- Converging evidence for a two-domain framework of microvascular dysfunction in sepsis.Critical care (London, England) · 2026Article
- Prognostic Performance of Shock Index, Whole-Blood Lactate Concentration, Rectal-Interdigital Temperature Gradient, and ATT Score in Cats with Trauma-Induced Shock.Animals : an open access journal from MDPI · 2026Article
- Diffuse alveolar damage, acute respiratory distress syndrome (ARDS), and non-cardiogenic pulmonary edema. Part 1: ARDS endotypes, including systemic inflammatory response syndrome and sepsis, with dog and cat examples.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2026Review
- ARISE framework: a temporal, multi-organ view of perfusion in sepsis.Internal and emergency medicine · 2026Review
- Positioning Statement on the Use of Point-of-Care Ultrasound in Cardiovascular Medicine - 2026.Arquivos brasileiros de cardiologia · 2026Article
- The Implementation Gap in Early Septic Shock Resuscitation: A Three-Barrier Framework.Journal of clinical medicine · 2026Article
- Nebivolol as a potential adjunct therapy for sepsis-induced cardiac dysfunction: evidence from a rat model.Scientific reports · 2026Article
- Papaverine Mitigates Acute Kidney Injury in Feces-Induced Polymicrobial Sepsis Through Regulation of the HMGB1-RAGE Axis.Medicina (Kaunas, Lithuania) · 2026Article
- Milrinone and levosimendan improve microvascular perfusion in septic rats: a randomized, placebo-controlled trial.Intensive care medicine experimental · 2026Article
128 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple experimental and human trials have shown that microcirculatory alterations are frequent in sepsis. In this review, we discuss the various mechanisms that are potentially involved in their development and the implications of these alterations. Endothelial dysfunction, impaired inter-cell communication, altered glycocalyx, adhesion and rolling of white blood cells and platelets, and altered red blood cell deformability are the main mechanisms involved in the development of these alterations. Microcirculatory alterations increase the diffusion distance for oxygen and, due to the heterogeneity of microcirculatory perfusion in sepsis, may promote development of areas of tissue hypoxia in close vicinity to well-oxygenated zones. The severity of microvascular alterations is associated with organ dysfunction and mortality. At this stage, therapies to specifically target the microcirculation are still being investigated.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.