Evidence map›Paper›PMID 24067381›Full record

ReviewCurrent opinion in rheumatology2013

Update in inclusion body myositis.

Pedro Machado, Stefen Brady, Michael G Hanna

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in rheumatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Current biomarkers in inclusion body myositis.Journal of neuromuscular diseases · 2024
    Review
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Targeted Molecular Therapies for SBMA.Journal of molecular neuroscience : MN · 2016
    Review
  14. The Role of the Protein Quality Control System in SBMA.Journal of molecular neuroscience : MN · 2016
    Review
  15. Treatment for inclusion body myositis.The Cochrane database of systematic reviews · 2015
    Review
  16. Article
  17. Review
  18. Article
  19. Inclusion body myositis.Neurologic clinics · 2014
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pedro MachadoMRC Centre for Neuromuscular Diseases, Institute of Neurology, University College London, London, UK *Pedro Machado and Stefen Brady have contributed equally to this article.
Stefen Brady
Michael G Hanna
National Hospital for Neurology and Neurosurgery · GB

Funding

Medical Research Council MR/K000608/01Medical Research Council MR/K000608/1
6 · The paper itself

Abstract

purpose of reviewThe purpose of this study is to review recent scientific advances relating to the natural history, cause, treatment and serum and imaging biomarkers of inclusion body myositis (IBM). RECENT

findingsSeveral theories regarding the aetiopathogenesis of IBM are being explored and new therapeutic approaches are being investigated. New diagnostic criteria have been proposed, reflecting the knowledge that the diagnostic pathological findings may be absent in patients with clinically typical IBM. The role of MRI in IBM is expanding and knowledge about pathological biomarkers is increasing. The recent description of autoantibodies to cytosolic 5' nucleotidase 1A in patients with IBM is a potentially important advance that may aid early diagnosis and provides new evidence regarding the role of autoimmunity in IBM. SUMMARY: IBM remains an enigmatic and often misdiagnosed disease. The pathogenesis of the disease is still not fully understood. To date, pharmacological treatment trials have failed to show clear efficacy. Future research should continue to focus on improving understanding of the pathophysiological mechanisms of the disease and on the identification of reliable and sensitive outcome measures for clinical trials. IBM is a rare disease and international multicentre collaboration for trials is important to translate research advances into improved patient outcomes.

Indexed as

5'-NucleotidaseAutoantibodiesBiomarkersHumansMagnetic Resonance ImagingMyositis, Inclusion Body5'-NucleotidaseAutoantibodiesBiomarkersNT5C1A protein, human

Identifiers

PMID24067381
PMCPMC4196838
OpenAlexW2023758879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.