Evidence map›Paper›PMID 24067301›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014

Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with asperger syndrome.

Gregor Domes, Ekkehardt Kumbier, Markus Heinrichs, Sabine C Herpertz

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 164 citations in OpenAlex.

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  5. Oxytocin effects on amygdala reactivity to angry faces in males and females with antisocial personality disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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  11. Oxytocin induces long-lasting adaptations within amygdala circuitry in autism: a treatment-mechanism study with randomized placebo-controlled design.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
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  14. Neural modulation of social reinforcement learning by intranasal oxytocin in male adults with high-functioning autism spectrum disorder: a randomized trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
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  17. Intranasal Oxytocin Administration Dampens Amygdala Reactivity towards Emotional Faces in Male and Female PTSD Patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Gregor Domes1] Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany [2] Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany.
Ekkehardt KumbierDepartment of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany.
Markus Heinrichs1] Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany [2] Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany.
Sabine C HerpertzDepartment of General Psychiatry, Center of Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany.
Heidelberg University · DEUniversity Medical Center Freiburg · DEUniversity of Freiburg · DEUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuropeptide oxytocin has recently been shown to enhance eye gaze and emotion recognition in healthy men. Here, we report a randomized double-blind, placebo-controlled trial that examined the neural and behavioral effects of a single dose of intranasal oxytocin on emotion recognition in individuals with Asperger syndrome (AS), a clinical condition characterized by impaired eye gaze and facial emotion recognition. Using functional magnetic resonance imaging, we examined whether oxytocin would enhance emotion recognition from facial sections of the eye vs the mouth region and modulate regional activity in brain areas associated with face perception in both adults with AS, and a neurotypical control group. Intranasal administration of the neuropeptide oxytocin improved performance in a facial emotion recognition task in individuals with AS. This was linked to increased left amygdala reactivity in response to facial stimuli and increased activity in the neural network involved in social cognition. Our data suggest that the amygdala, together with functionally associated cortical areas mediate the positive effect of oxytocin on social cognitive functioning in AS.

Indexed as

Administration, IntranasalAmygdalaAnalysis of VarianceAsperger SyndromeBiasCase-Control StudiesCross-Over StudiesDouble-Blind MethodDrug Administration ScheduleEmotionsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleOxygenOxytocinOxygenOxytocin

Identifiers

PMID24067301
PMCPMC3895247
OpenAlexW2078631866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.