ArticleAmerican journal of respiratory and critical care medicine2013
Indoor pollutant exposures modify the effect of airborne endotoxin on asthma in urban children.
Article in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Characterization of pesticide exposures and their associations with asthma morbidity in a predominantly low-income urban pediatric cohort in Baltimore City.Environmental research · 2024Article
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- Early life exposures of childhood asthma and allergies-an epidemiologic perspective.Frontiers in allergy · 2024Article
- Phthalate biomarkers and associations with respiratory symptoms and healthcare utilization among low-income urban children with asthma.Environmental research · 2022Article
- Air Quality Index and Emergency Department Visits and Hospitalizations for Childhood Asthma.Annals of the American Thoracic Society · 2022Article
- The influence of urban exposures and residence on childhood asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Review
- The Efficacy of the Dyson Air Purifier in Improving Asthma Control: Protocol for a Single-Center, Investigator-Led, Randomized, Double-Blind, Placebo-Controlled Trial.JMIR research protocols · 2021Article
- Current pet ownership modifies the adverse association between long-term ambient air pollution exposure and childhood asthma.Clinical and translational allergy · 2021Article
- Indoor endotoxin, proximity to a major roadway, and severe asthma exacerbations among children in Puerto Rico.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020Article
- Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome.Clinics in chest medicine · 2020Review
- Household airborne endotoxin associated with asthma and allergy in elementary school-age children: a case-control study in Kaohsiung, Taiwan.Environmental science and pollution research international · 2020Article
- Endotoxin clustering with allergens in house dust and asthma outcomes in a U.S. national study.Environmental health : a global access science source · 2020Article
- Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes.American journal of respiratory and critical care medicine · 2019Article
- Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities. An Analysis from SPIROMICS.Annals of the American Thoracic Society · 2018Article
- NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.The Journal of allergy and clinical immunology · 2017Article
- Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children.Journal of exposure science & environmental epidemiology · 2017Article
- Targeting patients with asthma for omalizumab therapy: choosing the right patient to get the best value for money.Therapeutic advances in chronic disease · 2017Review
- Whole Blood Cytokine Response to Local Traffic-Related Particulate Matter in Peruvian Children With and Without Asthma.Frontiers in pharmacology · 2017Article
- Domestic exposure to endotoxin and respiratory morbidity in former smokers with COPD.Indoor air · 2016Article
- Inner-city asthma: special considerations for management.Current opinion in allergy and clinical immunology · 2016Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleThe effect of endotoxin on asthma morbidity in urban populations is unclear.
objectivesTo determine if indoor pollutant exposure modifies the relationships between indoor airborne endotoxin and asthma health and morbidity.
methodsOne hundred forty-six children and adolescents with persistent asthma underwent repeated clinical assessments at 0, 3, 6, 9, and 12 months. Home visits were conducted at the same time points for assessment of airborne nicotine, endotoxin, and nitrogen dioxide (NO2) concentrations. The effect of concomitant pollutant exposure on relationships between endotoxin and asthma outcomes were examined in stratified analyses and statistical models with interaction terms. MEASUREMENTS AND MAIN
resultsBoth air nicotine and NO2 concentrations modified the relationships between airborne endotoxin and asthma outcomes. Among children living in homes with no detectable air nicotine, higher endotoxin was inversely associated with acute visits and oral corticosteroid bursts, whereas among those in homes with detectable air nicotine, endotoxin was positively associated with these outcomes (interaction P value = 0.004 and 0.07, respectively). Among children living in homes with lower NO2 concentrations (<20 ppb), higher endotoxin was positively associated with acute visits, whereas among those living in homes with higher NO2 concentrations, endotoxin was negatively associated with acute visit (interaction P value = 0.05). NO2 also modified the effect of endotoxin on asthma symptom outcomes in a similar manner.
conclusionsThe effects of household airborne endotoxin exposure on asthma are modified by coexposure to air nicotine and NO2, and these pollutants have opposite effects on the relationships between endotoxin and asthma-related outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.