ArticleBMC genomics2013
FGF2-induced effects on transcriptome associated with regeneration competence in adult human fibroblasts.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Probenecid-Mediated Pannexin-1 Inhibition Preserves βFGF-Driven Regenerative Responses in Human Dermal Fibroblasts.International journal of molecular sciences · 2026Article
- Comparative analysis of human and mouse transcriptomes during skin wound healing.Frontiers in cell and developmental biology · 2024Article
- Article
- Fibroblast growth factor-2 bound to specific dermal fibroblast-derived extracellular vesicles is protected from degradation.Scientific reports · 2022Article
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- Anti-fibrotic effects of pharmacologic FGF-2: a review of recent literature.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Fibroblast growth factor 2 inhibits myofibroblastic activation of valvular interstitial cells.PloS one · 2022Article
- Single Dose of N-Acetylcysteine in Local Anesthesia Increases Expression of HIF1α, MAPK1, TGFβ1 and Growth Factors in Rat Wound Healing.International journal of molecular sciences · 2021Article
- Review
- Deciphering the role of cartilage protein 1 in human dermal fibroblasts: a transcriptomic approach.Functional & integrative genomics · 2021Article
- Functional Properties of a Purified Reconstituted Bilayer Matrix Design Support Natural Wound Healing Activities.Plastic and reconstructive surgery. Global open · 2021Article
- Article
- Article
- Angiotensin-II-Evoked CaCells · 2020Article
- Required growth facilitators propel axon regeneration across complete spinal cord injury.Nature · 2018Article
- Fibroblast Growth Factor 2 as an Antifibrotic: Antagonism of Myofibroblast Differentiation and Suppression of Pro-Fibrotic Gene Expression.Cytokine & growth factor reviews · 2017Review
- FGF2-mediated attenuation of myofibroblast activation is modulated by distinct MAPK signaling pathways in human dermal fibroblasts.Journal of dermatological science · 2017Article
- JDINAC: joint density-based non-parametric differential interaction network analysis and classification using high-dimensional sparse omics data.Bioinformatics (Oxford, England) · 2017Article
- Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.Nature communications · 2016Article
- Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar.Journal of molecular histology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAdult human fibroblasts grown in low oxygen and with FGF2 supplementation have the capacity to tip the healing outcome of skeletal muscle injury - by favoring regeneration response in vivo over scar formation. Here, we compare the transcriptomes of control adult human dermal fibroblasts and induced regeneration-competent (iRC) fibroblasts to identify transcriptional changes that may be related to their regeneration competence.
resultsWe identified a unique gene-expression profile that characterizes FGF2-induced iRC fibroblast phenotype. Significantly differentially expressed genes due to FGF2 treatment were identified and analyzed to determine overrepresented Gene Ontology terms. Genes belonging to extracellular matrix components, adhesion molecules, matrix remodelling, cytoskeleton, and cytokines were determined to be affected by FGF2 treatment.
conclusionsTranscriptome analysis comparing control adult human fibroblasts with FGF2-treated fibroblasts identified functional groups of genes that reflect transcriptional changes potentially contributing to their regeneration competence. This comparative transcriptome analysis should contribute new insights into genes that characterize cells with greater regenerative potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.