ArticleThe International journal of oral & maxillofacial implants
Intraoral grafting of tissue-engineered human oral mucosa.
Article in The International journal of oral & maxillofacial implants. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Soft tissue substitutes in non-root coverage procedures: a systematic review and meta-analysis.Clinical oral investigations · 2017Pooled it
- Reconstruction of functional human lips utilizing a prelaminated flap.Frontiers in bioengineering and biotechnology · 2024Article
- First-in-Human Study to Investigate the Safety Assessment of Peri-Implant Soft Tissue Regeneration with Micronized-Gingival Connective Tissue: A Pilot Case Series Study.Medicines (Basel, Switzerland) · 2023Article
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- Bringing hydrogel-based craniofacial therapies to the clinic.Acta biomaterialia · 2022Review
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- Advances in Tissue Engineering and Implications for Oral and Maxillofacial Reconstruction.Journal of the California Dental Association · 2021Article
- Regulatory mechanism of oral mucosal rete peg formation.Journal of molecular histology · 2021Review
- Cells/colony motion of oral keratinocytes determined by non-invasive and quantitative measurement using optical flow predicts epithelial regenerative capacity.Scientific reports · 2021Article
- A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus.Frontiers in cell and developmental biology · 2021Review
- The clinical application of partial removal periodontal surgery in the therapy of epulis.Medicine · 2019Article
- Vertical distraction osteogenesis of a reconstructed mandible with a free vascularized fibula flap: a report of two cases.Maxillofacial plastic and reconstructive surgery · 2018Article
- Evaluation of oral keratinocyte progenitor and T-lymphocite cells response during early healing after augmentation of keratinized gingiva with a 3D collagen matrix - a pilot study.BMC oral health · 2016Article
- Human oral mucosa tissue-engineered constructs monitored by Raman fiber-optic probe.Tissue engineering. Part C, Methods · 2015Article
- The potential of label-free nonlinear optical molecular microscopy to non-invasively characterize the viability of engineered human tissue constructs.Biomaterials · 2014Article
- Hypoxia induces an undifferentiated phenotype of oral keratinocytes in vitro.Cells, tissues, organs · 2014Article
- Soft tissue engineering in craniomaxillofacial surgery.Annals of maxillofacial surgery · 2014Review
- Tissue-engineered constructs of human oral mucosa examined by Raman spectroscopy.Tissue engineering. Part C, Methods · 2013Article
- Tissue engineering of lips and muco-cutaneous junctions: in vitro development of tissue engineered constructs of oral mucosa and skin for lip reconstruction.Tissue engineering. Part C, Methods · 2012Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
purposeThe primary objective of this study was to evaluate the safety of a tissue-engineered human ex vivo-produced oral mucosa equivalent (EVPOME) in intraoral grafting procedures. The secondary objective was to assess the efficacy of the grafted EVPOME in producing a keratinized mucosal surface epithelium. MATERIALS AND
methodsFive patients who met the inclusion criteria of having one mucogingival defect or a lack of keratinized gingiva on a nonmolar tooth, along with radiographic evidence of sufficient interdental bone height, were recruited as subjects to increase the width of keratinized gingiva at the defect site. A punch biopsy specimen of the hard palate was taken to acquire oral keratinocytes, which were expanded, seeded, and cultured on an acellular dermal matrix for fabrication of an EVPOME. EVPOME grafts were applied directly over an intact periosteal bed and secured in place. At baseline (biopsy specimen retrieval) and at 7, 14, 30, 90, and 180 days postsurgery, Plaque Index and Gingival Index were recorded for each subject. In addition, probing depths, keratinized gingival width, and keratinized gingival thickness were recorded at baseline, 30, 90, and 180 days.
resultsNo complications or adverse reactions to EVPOME were observed in any subjects during the study. The mean gain in keratinized gingival width was 3 mm (range, 3 to 4 mm). The mean gain in keratinized gingival thickness was 1 mm (range, 1 to 2 mm). No significant changes in probing depths were observed.
conclusionBased on these findings, it can be concluded that EVPOME is safe for intraoral use and has the ability to augment keratinized tissue around teeth. Future clinical trials are needed to further explore this potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.