ArticleBioMed research international2013
Distal airway impairment in obese normoreactive women.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Overweight, Obesity, and Lung Function in Children and Adults-A Meta-analysis.The journal of allergy and clinical immunology. In practicePooled it
- Stomatognathic System Changes in Obese Patients Undergoing Bariatric Surgery: A Systematic Review.Journal of personalized medicine · 2022Review
- Review
- Imbalanced Coagulation in the Airway of Type-2 High Asthma with Comorbid Obesity.Journal of asthma and allergy · 2021Review
- Future treatment for asthma.European respiratory review : an official journal of the European Respiratory Society · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma-like symptoms are frequent in overweight and obesity, but the mechanism is unclear when airway hyperresponsiveness (AHR) is lacking. In this study, we focused on obese women with a clinical suspicion of asthma but negative methacholine challenge and tested distal airway hyperreactivity, explored by Forced Vital Capacity dose-response slope (FVC DRS).
objectiveTo question AHR at the distal airway level in obese women.
methodsA total of 293 symptomatic obese and nonobese women free of treatment were investigated. Methacholine challenge tests were undertaken, and patients were divided according to their results to the test. In hyperreactive and nonhyperreactive patients and in our total population, correlations, regression analyses, and analyses of covariance were performed to compare distal airway hyperreactivity in three groups of body mass index (BMI).
resultsAfter adjusting for age and baseline respiratory values, the relationship between FVC and FEV1 (forced expiratory volume in one second) DRS was influenced by BMI, with a lower slope in obese than overweight and normal patients in our total population (P = 0.008) and in our nonhyperreactive one (P = 0.028).
conclusionDistal airway hyperresponsiveness was observed in symptomatic wheezing obese women negative to methacholine challenge.
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Registered trials
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