ArticleOxidative medicine and cellular longevity2013
Status of systemic oxidative stress during therapeutic hypothermia in patients with post-cardiac arrest syndrome.
Article in Oxidative medicine and cellular longevity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Sedation Therapy in Intensive Care Units: Harnessing the Power of Antioxidants to Combat Oxidative Stress.Biomedicines · 2023Article
- Balance of the prooxidant and antioxidant system is associated with mortality in critically ill patients.Journal of clinical biochemistry and nutrition · 2023Article
- Increased plasma disequilibrium between pro- and anti-oxidants during the early phase resuscitation after cardiac arrest is associated with increased levels of oxidative stress end-products.Molecular medicine (Cambridge, Mass.) · 2021Article
- Therapeutic hypothermia effect on asphyxial cardiac arrest-induced renal ischemia/reperfusion injury via change of Nrf2/HO-1 levels.Experimental and therapeutic medicine · 2021Article
- Pharmacological Approach for Neuroprotection After Cardiac Arrest-A Narrative Review of Current Therapies and Future Neuroprotective Cocktail.Frontiers in medicine · 2021Review
- Healthful aging mediated by inhibition of oxidative stress.Ageing research reviews · 2020Review
- Therapeutic hypothermia reduces inflammation and oxidative stress in the liver after asphyxial cardiac arrest in rats.Acute and critical care · 2020Article
- Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome.Journal of clinical biochemistry and nutrition · 2020Article
- Therapeutic Hypothermia Improves Hind Limb Motor Outcome and Attenuates Oxidative Stress and Neuronal Damage in the Lumbar Spinal Cord Following Cardiac Arrest.Antioxidants (Basel, Switzerland) · 2020Article
- Endothelial Nitric Oxide Synthase-Independent Pleiotropic Effects of Pitavastatin Against Atherogenesis and Limb Ischemia in Mice.Journal of atherosclerosis and thrombosis · 2018Article
- Pathological effect of arterial ischaemia and venous congestion on rat testes.Scientific reports · 2017Article
- Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration.Journal of clinical biochemistry and nutrition · 2017Review
- Effect of oral carbohydrate with amino acid solution on serum oxidative/anti-oxidative status in healthy volunteers.Journal of anesthesia · 2017Article
- Therapeutic Hypothermia Reduces Oxidative Damage and Alters Antioxidant Defenses after Cardiac Arrest.Oxidative medicine and cellular longevity · 2017Observational
- Hyperoxia toxicity after cardiac arrest: What is the evidence?Annals of intensive care · 2016Review
- Influence of smoking on perioperative oxidative stress after pulmonary resection.Surgery today · 2016Article
- Hypothermia and Rewarming Activate a Macroglial Unfolded Protein Response Independent of Hypoxic-Ischemic Brain Injury in Neonatal Piglets.Developmental neuroscience · 2016Article
- Exposure to high concentrations of inspired oxygen does not worsen lung injury after cardiac arrest.Critical care (London, England) · 2015Review
- The association between hyperoxia and patient outcomes after cardiac arrest: analysis of a high-resolution database.Intensive care medicine · 2015Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapeutic hypothermia (TH) is thought to be due to the downregulation of free radical production, although the details of this process remain unclear. Here, we investigate changes in oxidative stress and endogenous biological antioxidant potential during TH in patients with post-cardiac arrest syndrome (PCAS). Nineteen PCAS patients were enrolled in the study. Brain temperature was decreased to the target temperature of 33°C, and it was maintained for 24 h. Patients were rewarmed slowly (0.1°C/h, <1°C/day). The generation of reactive oxygen metabolites (ROMs) was evaluated in plasma samples by d-ROM test. Plasma antioxidant capacity was measured by the biological antioxidant potential (BAP) test. Levels of d-ROMs and BAP levels during the hypothermic stage (33°C) were suppressed significantly compared with pre-TH induction levels (P < 0.05), while both d-ROM and BAP levels increased with rewarming (33-36°C) and were correlated with brain temperature. Clinical monitoring of oxidative stress and antioxidant potential is useful for evaluating the redox state of patients undergoing TH after PCAS. Additional therapy to support the antioxidant potential in the rewarming stage following TH may reduce some of the observed side effects associated with the use of TH.
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