ArticlePloS one2013
Campylobacter jejuni colonization is associated with a dysbiosis in the cecal microbiota of mice in the absence of prominent inflammation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Peeling back the many layers of competitive exclusion.Frontiers in microbiology · 2024Article
- Effects of Sublethally Injured Campylobacter jejuni in Mice.Microbiology spectrum · 2022Article
- Bacterial composition of a competitive exclusion product and its correlation with product efficacy at reducingFrontiers in physiology · 2022Article
- Strength Lies in Diversity: How Community Diversity LimitsFrontiers in microbiology · 2021Article
- Clinically Relevant Campylobacter jejuni Subtypes Are Readily Found and Transmitted within the Cattle Production Continuum but Present a Limited Foodborne Risk.Applied and environmental microbiology · 2020Article
- Tetracycline ResistantMicroorganisms · 2019Article
- Article
- Pathobiont release from dysbiotic gut microbiota biofilms in intestinal inflammatory diseases: a role for iron?Journal of biomedical science · 2019Review
- The Effect of Co-infection of Food-Borne Pathogenic Bacteria on the Progression ofFrontiers in microbiology · 2018Article
- β-Defensins: Farming the Microbiome for Homeostasis and Health.Frontiers in immunology · 2018Review
- Evaluation and optimization of microbial DNA extraction from fecal samples of wild Antarctic bird species.Infection ecology & epidemiology · 2017Article
- Changes in bacterial community composition of Escherichia coli O157:H7 super-shedder cattle occur in the lower intestine.PloS one · 2017Article
- Antimicrobial growth promoters modulate host responses in mice with a defined intestinal microbiota.Scientific reports · 2016Article
- Monitoring chicken flock behaviour provides early warning of infection by human pathogen Campylobacter.Proceedings. Biological sciences · 2016Article
- Biochar, Bentonite and Zeolite Supplemented Feeding of Layer Chickens Alters Intestinal Microbiota and Reduces Campylobacter Load.PloS one · 2016Article
- The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor.Gut microbes · 2014Article
- Comparative variation within the genome of Campylobacter jejuni NCTC 11168 in human and murine hosts.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCampylobacter jejuni causes enterocolitis in humans, but does not incite disease in asymptomatic carrier animals. To survive in the intestine, C. jejuni must successfully compete with the microbiota and overcome the host immune defense. Campylobacter jejuni colonization success varies considerably amongst individual mice, and we examined the degree to which the intestinal microbiota was affected in mice (i.e. a model carrier animal) colonized by C. jejuni at high relative to low densities.
methodsMice were inoculated with C. jejuni or buffer, and pathogen shedding and intestinal colonization were measured. Histopathologic scoring and quantification of mRNA expression for α-defensins, toll-like receptors, and cytokine genes were conducted. Mucosa-associated bacterial communities were characterized by two approaches: multiplexed barcoded pyrosequencing and terminal restriction fragment length polymorphism analysis.
resultsTwo C. jejuni treatments were established based on the degree of cecal and colonic colonization; C. jejuni Group A animals were colonized at high cell densities, and C. jejuni Group B animals were colonized at lower cell densities. Histological examination of cecal and colonic tissues indicated that C. jejuni did not incite visible pathologic changes. Although there was no significant difference among treatments in expression of mRNA for α-defensins, toll-like receptors, or cytokine genes, a trend for increased expression of toll-like receptors and cytokine genes was observed for C. jejuni Group A. The results of the two methods to characterize bacterial communities indicated that the composition of the cecal microbiota of C. jejuni Group A mice differed significantly from C. jejuni Group B and Control mice. This difference was due to a reduction in load, diversity and richness of bacteria associated with the cecal mucosa of C. jejuni Group A mice.
conclusionsHigh density colonization by C. jejuni is associated with a dysbiosis in the cecal microbiota independent of prominent inflammation.
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