ArticlePloS one2013
Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Racial disparities in colorectal cancer clinicopathological and molecular tumor characteristics: a systematic review.Cancer causes & control : CCC · 2024Pooled it
- Distinct Driver Pathway Enrichments and a High Prevalence ofInternational journal of molecular sciences · 2024Article
- Genomic and transcriptomic analysis of Korean colorectal cancer patients.Genes & genomics · 2022Article
- Molecular Analysis of Colorectal Cancers Suggests a High Frequency of Lynch Syndrome in Indonesia.Cancers · 2021Article
- Mutation Status and Prognostic Value of KRAS and BRAF in Southeast Iranian Colorectal Cancer Patients: First Report from Southeast of Iran.Journal of gastrointestinal cancer · 2021Article
- A modified screening strategy for Lynch syndrome among MLH1-deficient CRCs: Analysis from consecutive Chinese patients in a single center.Translational oncology · 2021Article
- Article
- Risk Haplotypes Uniquely Associated with Radioiodine-Refractory Thyroid Cancer Patients of High African Ancestry.Thyroid : official journal of the American Thyroid Association · 2019Article
- Clinicopathological Significance ofJournal of Cancer · 2019Article
- Clinical significance of the BRAFV600E mutation in Asian patients with colorectal cancer.International journal of colorectal disease · 2018Article
- Clinicopathological Associations of K-RAS and N-RAS Mutations in Indonesian Colorectal Cancer Cohort.Journal of gastrointestinal cancer · 2018Article
- Prostate Cancer Genomics: Recent Advances and the Prevailing Underrepresentation from Racial and Ethnic Minorities.International journal of molecular sciences · 2018Review
- Development of ultra-short PCR assay to reveal BRAF V600 mutation status in Thai colorectal cancer tissues.PloS one · 2018Article
- Increased Frequency of KRAS Mutations in African Americans Compared with Caucasians in Sporadic Colorectal Cancer.Clinical and translational gastroenterology · 2017Article
- Racial disparity in metabolic regulation of cancer.Frontiers in bioscience (Landmark edition) · 2017Review
- Clinical, Sonographic, and Pathological Characteristics of RAS-Positive Versus BRAF-Positive Thyroid Carcinoma.The Journal of clinical endocrinology and metabolism · 2016Article
- Molecular Biomarkers of Colorectal Cancer and Cancer Disparities: Current Status and Perspective.Current colorectal cancer reports · 2016Article
- KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients.World journal of gastroenterology · 2015Article
- Article
- Colorectal cancer in iran: molecular epidemiology and screening strategies.Journal of cancer epidemiology · 2015Review
Corrections and comments
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Authors and funding
21 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been demonstrated for some cancers that the frequency of somatic oncogenic mutations may vary in ancestral populations. To determine whether key driver alterations might occur at different frequencies in colorectal cancer, we applied a high-throughput genotyping platform (OncoMap) to query 385 mutations across 33 known cancer genes in colorectal cancer DNA from 83 Asian, 149 Black and 195 White patients. We found that Asian patients had fewer canonical oncogenic mutations in the genes tested (60% vs Black 79% (P = 0.011) and White 77% (P = 0.015)), and that BRAF mutations occurred at a higher frequency in White patients (17% vs Asian 4% (P = 0.004) and Black 7% (P = 0.014)). These results suggest that the use of genomic approaches to elucidate the different ancestral determinants harbored by patient populations may help to more precisely and effectively treat colorectal cancer.
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