ArticlePloS one2013
Long-term evolution of brainstem electrical evoked responses to sound after restricted ablation of the auditory cortex.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- The effect of doxorubicin or cyclophosphamide treatment on auditory brainstem response in mice.Experimental brain research · 2022Article
- Auditory Behavior in Adult-Blinded Mice.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- What can we learn from inactivation studies? Lessons from auditory cortex.Trends in neurosciences · 2022Review
- Effects of Multisession Anodal Electrical Stimulation of the Auditory Cortex on Temporary Noise-Induced Hearing Loss in the Rat.Frontiers in neuroscience · 2021Article
- Reversible Functional Changes Evoked by Anodal Epidural Direct Current Electrical Stimulation of the Rat Auditory Cortex.Frontiers in neuroscience · 2019Article
- Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain.Journal of visualized experiments : JoVE · 2017Article
- Article
- All the way from the cortex: a review of auditory corticosubcollicular pathways.Cerebellum (London, England) · 2015Review
- The olivocochlear reflex strength and cochlear sensitivity are independently modulated by auditory cortex microstimulation.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
- Sensory cortex lesion triggers compensatory neuronal plasticity.BMC neuroscience · 2014Article
- Acoustic input and efferent activity regulate the expression of molecules involved in cochlear micromechanics.Frontiers in systems neuroscience · 2014Article
- Hearing impairment in the P23H-1 retinal degeneration rat model.Frontiers in neuroscience · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to assess the top-down control of sound processing in the auditory brainstem of rats. Short latency evoked responses were analyzed after unilateral or bilateral ablation of auditory cortex. This experimental paradigm was also used towards analyzing the long-term evolution of post-lesion plasticity in the auditory system and its ability to self-repair.
methodAuditory cortex lesions were performed in rats by stereotactically guided fine-needle aspiration of the cerebrocortical surface. Auditory Brainstem Responses (ABR) were recorded at post-surgery day (PSD) 1, 7, 15 and 30. Recordings were performed under closed-field conditions, using click trains at different sound intensity levels, followed by statistical analysis of threshold values and ABR amplitude and latency variables. Subsequently, brains were sectioned and immunostained for GAD and parvalbumin to assess the location and extent of lesions accurately.
resultsAlterations in ABR variables depended on the type of lesion and post-surgery time of ABR recordings. Accordingly, bilateral ablations caused a statistically significant increase in thresholds at PSD1 and 7 and a decrease in waves amplitudes at PSD1 that recover at PSD7. No effects on latency were noted at PSD1 and 7, whilst recordings at PSD15 and 30 showed statistically significant decreases in latency. Conversely, unilateral ablations had no effect on auditory thresholds or latencies, while wave amplitudes only decreased at PSD1 strictly in the ipsilateral ear.
conclusionPost-lesion plasticity in the auditory system acts in two time periods: short-term period of decreased sound sensitivity (until PSD7), most likely resulting from axonal degeneration; and a long-term period (up to PSD7), with changes in latency responses and recovery of thresholds and amplitudes values. The cerebral cortex may have a net positive gain on the auditory pathway response to sound.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.