ArticlePloS one2013
A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 23 citations in OpenAlex.
- 3D-visualization of segmented contacts of directional deep brain stimulation electrodes via registration and fusion of CT and FDCT.EJNMMI reports · 2024Article
- Thalamo-cortical evoked potentials during stimulation of the dentato-rubro-thalamic tract demonstrate synaptic filtering.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Article
- Automated Detection of Enhanced DBS Device Settings.Companion Publication of the 2020 International Conference on Multimodal Interaction · 2020Article
- Deep brain stimulation for Parkinson's disease modulates high-frequency evoked and spontaneous neural activity.Neurobiology of disease · 2019Article
- Mechanisms of deep brain stimulation.Journal of neurophysiology · 2016Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinsonian and essential tremor can often be effectively treated by deep brain stimulation. We propose a novel explanation for the mechanism by which this technique ameliorates tremor: a reduction of the delay in the relevant motor control loops via preferential antidromic blockade of slow axons. The antidromic blockade is preferential because the pulses more rapidly clear fast axons, and the distribution of axonal diameters, and therefore velocities, in the involved tracts, is sufficiently long-tailed to make this effect quite significant. The preferential blockade of slow axons, combined with gain adaptation, results in a reduction of the mean delay in the motor control loop, which serves to stabilize the feedback system, thus ameliorating tremor. This theory, without any tuning, accounts for several previously perplexing phenomena, and makes a variety of novel predictions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.