ReviewFrontiers in plant science2013
Thiol-based redox control of enzymes involved in the tetrapyrrole biosynthesis pathway in plants.
Review in Frontiers in plant science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Structures of LPOR-Chlide complexes reveal the structural basis of membrane remodeling and photocatalysis.Nature communications · 2026Article
- Redox regulation of glutamate-1-semialdehyde aminotransferase modulates the synthesis of 5-aminolevulinic acid in Arabidopsis.Frontiers in plant science · 2025Article
- Chlorophyllase fromACS bio & med chem Au · 2024Article
- Article
- Current Insights into the Redox Regulation Network in Plant Chloroplasts.Plant & cell physiology · 2023Review
- Article
- A structure-function analysis of chlorophyllase reveals a mechanism for activity regulation dependent on disulfide bonds.The Journal of biological chemistry · 2023Article
- Impact of Porphyrin Binding to GENOMES UNCOUPLED 4 on Tetrapyrrole BiosynthesisFrontiers in plant science · 2022Article
- Exogenous Application of 5-Aminolevulinic Acid Promotes Coloration and Improves the Quality of Tomato Fruit by Regulating Carotenoid Metabolism.Frontiers in plant science · 2021Article
- The Role of Membranes and Lipid-Protein Interactions in the Mg-Branch of Tetrapyrrole Biosynthesis.Frontiers in plant science · 2021Review
- Photosynthetic Metabolism and Nitrogen Reshuffling Are Regulated by Reversible Cysteine Thiol Oxidation Following Nitrogen Deprivation in Chlamydomonas.Plants (Basel, Switzerland) · 2020Article
- Is there a role for tau glutathione transferases in tetrapyrrole metabolism and retrograde signalling in plants?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- NTRC and Thioredoxin f Overexpression Differentially Induces Starch Accumulation in Tobacco Leaves.Plants (Basel, Switzerland) · 2019Article
- Exogenous GABA enhances muskmelon tolerance to salinity-alkalinity stress by regulating redox balance and chlorophyll biosynthesis.BMC plant biology · 2019Article
- The function of PROTOPORPHYRINOGEN IX OXIDASE in chlorophyll biosynthesis requires oxidised plastoquinone inCommunications biology · 2019Article
- Towards Initial Indications for a Thiol-Based Redox Control of Arabidopsis 5-Aminolevulinic Acid Dehydratase.Antioxidants (Basel, Switzerland) · 2018Article
- M-type thioredoxins are involved in the xanthophyll cycle and proton motive force to alter NPQ under low-light conditions in Arabidopsis.Plant cell reports · 2018Article
- 5-Aminolevulinic Acid (ALA) Alleviated Salinity Stress in Cucumber Seedlings by Enhancing Chlorophyll Synthesis Pathway.Frontiers in plant science · 2018Article
- Thioredoxin and NADPH-Dependent Thioredoxin Reductase C Regulation of Tetrapyrrole Biosynthesis.Plant physiology · 2017Article
- Phosphorylation of GENOMES UNCOUPLED 4 Alters Stimulation of Mg Chelatase Activity in Angiosperms.Plant physiology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The last decades of research brought substantial insights into tetrapyrrole biosynthetic pathway in photosynthetic organisms. Almost all genes have been identified and roles of seemingly all essential proteins, leading to the synthesis of heme, siroheme, phytochromobilin, and chlorophyll (Chl), have been characterized. Detailed studies revealed the existence of a complex network of transcriptional and post-translational control mechanisms for maintaining a well-adjusted tetrapyrrole biosynthesis during plant development and adequate responses to environmental changes. Among others one of the known post-translational modifications is regulation of enzyme activities by redox modulators. Thioredoxins and NADPH-dependent thioredoxin reductase C (NTRC) adjust the activity of tetrapyrrole synthesis to the redox status of plastids. Excessive excitation energy of Chls in both photosystems and accumulation of light-absorbing unbound tetrapyrrole intermediates generate reactive oxygen species, which interfere with the plastid redox poise. Recent reports highlight ferredoxin-thioredoxin and NTRC-dependent control of key steps in tetrapyrrole biosynthesis in plants. In this review we introduce the regulatory impact of these reductants on the stability and activity of enzymes involved in 5-aminolevulinic acid synthesis as well as in the Mg-branch of the tetrapyrrole biosynthetic pathway and we propose molecular mechanisms behind this redox control.
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