Evidence map›Paper›PMID 24065930›Full record

ArticleFrontiers in psychiatry2013

Transcranial direct current stimulation reduces negative affect but not cigarette craving in overnight abstinent smokers.

Jiansong Xu, Felipe Fregni, Arthur L Brody, Ardeshir S Rahman

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01721473 completednot on this map

Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers

TypeobservationalSponsorVA Office of Research and DevelopmentRan2012 to 2016Enrolled184ConditionsPositron Emission TomographyArmspositron emission tomography scan
NCT02178852 phase1 / phase2unknown statusnot on this mapstarted 2014, after this paper: background citation

Effect of Trigeminal Nerve Stimulation (TNS) on Nicotine Craving: Phase II, Cross-over, Randomized, Sham-controlled Clinical Trial

TypeinterventionalSponsorSanta Casa Medical SchoolRan2014Enrolled22ConditionsNicotine CravingArmsTRIGEMINAL NERVE STIMULATION (TNS)
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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  18. Brain stimulation therapeutics.Addiction neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiansong XuDepartment of Psychiatry, Yale Medical School , New Haven, CT , USA.
Felipe Fregni
Arthur L Brody
Ardeshir S Rahman

Funding

FMRI & DTI Study on Neural Predictor of Treatment Outcome of Cocaine DependenceK01DA027750 · NIDA · YALE UNIVERSITY · PI XU, JIANSONG · 2010 to 2014
$881k
Nicotinic Acetylcholine Receptor Density and Veteran Cigarette SmokersI01CX000412 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI BRODY, ARTHUR · 2013 to 2017
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CSRD VA I01 CX000412NIDA NIH HHS K01 DA027750
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) can enhance cognitive control functions including attention and top-down regulation over negative affect and substance craving in both healthy and clinical populations, including early abstinent (∼1.5 h) smokers. The aim of this study was to assess whether tDCS modulates negative affect, cigarette craving, and attention of overnight abstinent tobacco dependent smokers. In this study, 24 smokers received a real and a sham session of tDCS after overnight abstinence from smoking on two different days. We applied anode to the left dorsolateral prefrontal cortex and cathode to the right supra-orbital area for 20 min with a current of 2.0 mA. We used self-report questionnaires Profile of Mood States (POMS) to assess negative affect and Urge to Smoke (UTS) Scale to assess craving for cigarette smoking, and a computerized visual target identification task to assess attention immediately before and after each tDCS. Smokers reported significantly greater reductions in POMS scores of total mood disturbance and scores of tension-anxiety, depression-dejection, and confusion-bewilderment subscales after real relative to sham tDCS. Furthermore, this reduction in negative affect positively correlated with the level of nicotine dependence as assessed by Fagerström scale. However, reductions in cigarette craving after real vs. sham tDCS did not differ, nor were there differences in reaction time or hit rate change on the visual task. Smokers did not report significant side effects of tDCS. This study demonstrates the safety of tDCS and its promising effect in ameliorating negative affect in overnight abstinent smokers. Its efficacy in treating tobacco dependence deserves further investigation.

Indexed as

brain stimulationcigarette cravingnegative affectsmoking abstinencetobacco dependencetranscranial direct current stimulation

Identifiers

PMID24065930
PMCPMC3778370

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.