ArticleFrontiers in pharmacology2013
Acute nicotine administration effects on fractional anisotropy of cerebral white matter and associated attention performance.
Article in Frontiers in pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- White matter development and tobacco smoking in young adults: A systematic review with recommendations for future research.Drug and alcohol dependence · 2016Pooled it
- The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging.Human brain mapping · 2022Article
- White matter microstructure differences in individuals with dependence on cocaine, methamphetamine, and nicotine: Findings from the ENIGMA-Addiction working group.Drug and alcohol dependence · 2022Article
- White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy.Frontiers in neuroscience · 2021Article
- Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia.Molecular psychiatry · 2020Article
- Microstructural damage of white-matter tracts connecting large-scale networks is related to impaired executive profile in alcohol use disorder.NeuroImage. Clinical · 2020Article
- Associations between modifiable risk factors and white matter of the aging brain: insights from diffusion tensor imaging studies.Neurobiology of aging · 2019Review
- Nicotine Effects on White Matter Microstructure in Young Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2019Article
- Task-relevant brain networks identified with simultaneous PET/MR imaging of metabolism and connectivity.Brain structure & function · 2018Article
- Human brain imaging of nicotinic acetylcholine α4β2* receptors using [The Journal of comparative neurology · 2018Article
- Altered White Matter Integrity in Smokers Is Associated with Smoking Cessation Outcomes.Frontiers in human neuroscience · 2017Article
- Anterior cingulum white matter is altered in tobacco smokers.The American journal on addictions · 2016Article
- Frontal fasciculi and psychotic symptoms in antipsychotic-naive patients with schizophrenia before and after 6 weeks of selective dopamine D2/3 receptor blockade.Journal of psychiatry & neuroscience : JPN · 2016Article
- Smoking and the developing brain: altered white matter microstructure in attention-deficit/hyperactivity disorder and healthy controls.Human brain mapping · 2015Article
- Alterations in interhemispheric functional and anatomical connectivity are associated with tobacco smoking in humans.Frontiers in human neuroscience · 2015Article
- Neuroimaging in Alcohol and Drug Dependence.Current behavioral neuroscience reports · 2014Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
introductionNicotinic acetylcholine receptors are present in the cerebral white matter (WM). We hypothesized that WM response to nicotine can be detected by diffusion tensor imaging (DTI); and that such responses may be associated with nicotine-led cognitive enhancement in sustained attention.
methodsA randomized, nicotine-placebo patch, crossover, double-blind clinical trial in two non-overlapping cohorts of smokers was used to test the hypothesis. The discovery cohort consisted of 39 subjects (N = 20/19 controls/schizophrenic patients, age = 36.8 ± 10.1 years) and the replication cohorts consisted of 38 healthy smokers (31.7 ± 10.5 years). WM integrity was measured by fractional anisotropy (FA) values for the whole brain and nine preselected WM tracts using tract-based-spatial-statistics.
resultsNicotine significantly enhanced FA values for the genu of corpus callosum compared with placebo (ΔFAgenu) (p = 0.01) in smokers with low recent smoking exposure as measured by low average cotinine level. This finding was replicated in the second cohort (p = 0.02). ΔFAgenu values explained 22% of variance in performance of a sustained attention task during the nicotine session (p = 0.006). However, this effect was limited to schizophrenia patients (r = 0.62 and 0.09; p = 0.003 and 0.7 for patients and controls, respectively).
conclusionAcute pharmacological influence of nicotine patch on WM integrity appeared present, but was dependent on nicotine intake from recent smoking. Change in the WM integrity in the genu of corpus callosum was associated with a significant proportion of variability of nicotine-led changes in sustained attention/working memory of the smokers. Further studies will be necessary to understand biophysical underpinning of the nicotine-related changes in FA.
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