ArticleFrontiers in cellular neuroscience2013
Age dependency of trauma-induced neocortical epileptogenesis.
Article in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Pathophysiology of Status Epilepticus Revisited.International journal of molecular sciences · 2025Review
- Network effects of traumatic brain injury: from infra slow to high frequency oscillations and seizures.Journal of computational neuroscience · 2025Article
- Of the Mechanisms of Paroxysmal Depolarization Shifts: Generation and Maintenance of Bicuculline-Induced Paroxysmal Activity in Rat Hippocampal Cell Cultures.International journal of molecular sciences · 2023Article
- Putative roles for homeostatic plasticity in epileptogenesis.Epilepsia · 2023Review
- Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions.Pharmacological reviews · 2022Review
- Enhanced Interplay of Neuronal Coherence and Coupling in the Dying Human Brain.Frontiers in aging neuroscience · 2022Article
- Integrity of Corpus Callosum Is Essential for theCross-Hemispheric Propagation of Sleep Slow Waves:A High-Density EEG Study in Split-Brain Patients.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Sleep spindles are resilient to extensive white matter deterioration.Brain communications · 2020Article
- Ionic and synaptic mechanisms of seizure generation and epileptogenesis.Neurobiology of disease · 2019Review
- Brain white matter damage and its association with neuronal synchrony during sleep.Brain : a journal of neurology · 2019Article
- In vivo models of cortical acquired epilepsy.Journal of neuroscience methods · 2016Review
- Modeling of Age-Dependent Epileptogenesis by Differential Homeostatic Synaptic Scaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Changes in long-range connectivity and neuronal reorganization in partial cortical deafferentation model of epileptogenesis.Neuroscience · 2015Article
- Neuronal mechanisms of epileptogenesis.Frontiers in cellular neuroscience · 2014Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Trauma and brain infection are the primary sources of acquired epilepsy, which can occur at any age and may account for a high incidence of epilepsy in developing countries. We have explored the hypothesis that penetrating cortical wounds cause deafferentation of the neocortex, which triggers homeostatic plasticity and lead to epileptogenesis (Houweling etal., 2005). In partial deafferentation experiments of adult cats, acute seizures occurred in most preparations and chronic seizures occurred weeks to months after the operation in 65% of the animals (Nita etal., 2006,2007; Nita and Timofeev, 2007). Similar deafferentation of young cats (age 8-12 months) led to some acute seizures, but we never observed chronic seizure activity even though there was enhanced slow-wave activity in the partially deafferented hemisphere during quiet wakefulness. This suggests that despite a major trauma, the homeostatic plasticity in young animals was able to restore normal levels of cortical excitability, but in fully adult cats the mechanisms underlying homeostatic plasticity may lead to an unstable cortical state. To test this hypothesis we made an undercut in the cortex of an elderly cat. After several weeks this animal developed seizure activity. These observations may lead to an intervention after brain trauma that prevents epileptogenesis from occurring in adults.
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