ArticleProceedings of the National Academy of Sciences of the United States of America2013
Size homeostasis in adherent cells studied by synthetic phase microscopy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 105 citations in OpenAlex.
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- Stochasticity in mammalian cell growth rates drives cell-to-cell variability independently of cell size and divisions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Scanless temporal focusing enables high-speed three-dimensional quantitative phase microscopy.bioRxiv : the preprint server for biology · 2026Article
- A generalized adder for cell size homeostasis: Effects on stochastic clonal proliferation.Biophysical journal · 2025Article
- A GeneralizedbioRxiv : the preprint server for biology · 2024Article
- Towards ultrafast quantitative phase imaging via differentiable microscopy [Invited].Biomedical optics express · 2024Article
- Cell size homeostasis is tightly controlled throughout the cell cycle.PLoS biology · 2024Article
- Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells.Biosensors · 2023Article
- Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs.Clinical and experimental medicine · 2023Article
- Dry mass photometry of single bacteria using quantitative wavefront microscopy.Biophysical journal · 2023Article
- Deep learning-based label-free hematology analysis framework using optical diffraction tomography.Heliyon · 2023Article
- Spectroscopic Microtomography in the Short-Wave Infrared Wavelength Range.Sensors (Basel, Switzerland) · 2023Article
- Plasmids Can Shift Bacterial Morphological Response against Antibiotic Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Biomass measurements of single neuritesBiomedical optics express · 2022Article
- Cell growth and the cell cycle: New insights about persistent questions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Review
- Article
- The effect of pupil transmittance on axial resolution of reflection phase microscopy.Scientific reports · 2021Article
- The Relative Densities of Cytoplasm and Nuclear Compartments Are Robust against Strong Perturbation.Biophysical journal · 2020Article
- Computationally enhanced quantitative phase microscopy reveals autonomous oscillations in mammalian cell growth.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Scaling of Subcellular Structures.Annual review of cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
The coupling of the rate of cell growth to the rate of cell division determines cell size, a defining characteristic that is central to cell function and, ultimately, to tissue architecture. The physiology of size homeostasis has fascinated generations of biologists, but the mechanism, challenged by experimental limitations, remains largely unknown. In this paper, we propose a unique optical method that can measure the dry mass of thick live cells as accurately as that for thin cells with high computational efficiency. With this technique, we quantify, with unprecedented accuracy, the asymmetry of division in lymphoblasts and epithelial cells. We can then use the Collins-Richmond model of conservation to compute the relationship between growth rate and cell mass. In attached epithelial cells, we find that due to the asymmetry in cell division and size-dependent growth rate, there is active regulation of cell size. Thus, like nonadherent cells, size homeostasis requires feedback control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.