ArticleProceedings of the National Academy of Sciences of the United States of America2013
Self-organized optical device driven by motor proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
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- Building on-chip cytoskeletal circuits via branched microtubule networks.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Contractile and Tensile Measurement of Molecular Artificial Muscles for Biohybrid Robotics.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Surface-limited reactions for spatial control of kinesin-microtubule motility assays using indirect irradiation of an electron beam.Biomicrofluidics · 2022Article
- Linking path and filament persistence lengths of microtubules gliding over kinesin.Scientific reports · 2022Article
- Nano/Micromotors in Active Matter.Micromachines · 2022Review
- A printable active network actuator built from an engineered biomolecular motor.Nature materials · 2021Article
- Molecular Encapsulation Inside Microtubules Based on Tau-Derived Peptides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Magnetic Cytoskeleton Affinity Purification of Microtubule Motors Conjugated to Quantum Dots.Bioconjugate chemistry · 2018Article
- Non-equilibrium assembly of microtubules: from molecules to autonomous chemical robots.Chemical Society reviews · 2017Review
- Constructing 3D microtubule networks using holographic optical trapping.Scientific reports · 2015Article
- Negative differential electrical resistance of a rotational organic nanomotor.Beilstein journal of nanotechnology · 2015Article
- Molecular motors: DNA takes control.Nature nanotechnology · 2014Article
- Micropattern-guided assembly of overlapping pairs of dynamic microtubules.Methods in enzymology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein molecules produce diverse functions according to their combination and arrangement as is evident in a living cell. Therefore, they have a great potential for application in future devices. However, it is currently very difficult to construct systems in which a large number of different protein molecules work cooperatively. As an approach to this challenge, we arranged protein molecules in artificial microstructures and assembled an optical device inspired by a molecular system of a fish melanophore. We prepared arrays of cell-like microchambers, each of which contained a scaffold of microtubule seeds at the center. By polymerizing tubulin from the fixed microtubule seeds, we obtained radially arranged microtubules in the chambers. We subsequently prepared pigment granules associated with dynein motors and attached them to the radial microtubule arrays, which made a melanophore-like system. When ATP was added to the system, the color patterns of the chamber successfully changed, due to active transportation of pigments. Furthermore, as an application of the system, image formation on the array of the optical units was performed. This study demonstrates that a properly designed microstructure facilitates arrangement and self-organization of molecules and enables assembly of functional molecular systems.
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