ArticleProceedings of the National Academy of Sciences of the United States of America2013
Variation in the interaction between alleles of HvAPETALA2 and microRNA172 determines the density of grains on the barley inflorescence.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- Auxin-related regulation of barley floral organ fate: genetic and phenotypic insights from tweaky spike mutants.The New phytologist · 2026Article
- Copper-sensitive OsSPL9 TF regulates expression of indica rice domestication-associated miRNAs and phenotypes.Communications biology · 2026Article
- Functional 5Bq allele is responsible for the compact spike phenotype in common wheat (Triticum aestivum L.).BMC plant biology · 2026Article
- Pleiotropic effects of barley BLADE-ON-PETIOLE gene Uniculme4 on plant architecture and the jasmonic acid pathway.Journal of experimental botany · 2025Article
- Fine mapping and candidate gene mining of QSc/Sl.cib-7H for spike compactness and length and its pleiotropic effects on yield-related traits in barley (Hordeum vulgare L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A guide to barley mutants.Hereditas · 2024Review
- Accumulation of mutations in theMolecular breeding : new strategies in plant improvement · 2024Article
- Dynamic Phytomeric Growth Contributes to Local Adaptation in Barley.Molecular biology and evolution · 2024Article
- Mutations within the miR172 target site of wheatBreeding science · 2023Article
- CRISPR/Cas9 editing of wheat Ppd-1 gene homoeologs alters spike architecture and grain morphometric traits.Functional & integrative genomics · 2023Article
- Identification of a candidate dwarfing gene in Pallas, the first commercial barley cultivar generated through mutational breeding.Frontiers in genetics · 2023Article
- Article
- FIND-IT: Accelerated trait development for a green evolution.Science advances · 2022Article
- TheInternational journal of molecular sciences · 2022Article
- MicroRNA-resistant alleles ofScience advances · 2022Article
- Epigenetics and its role in effecting agronomical traits.Frontiers in plant science · 2022Review
- Identification of microRNAs Responding to Aluminium, Cadmium and Salt Stresses in Barley Roots.Plants (Basel, Switzerland) · 2021Article
- A novel mutant allele at the Cleistogamy 1 locus in barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Analysis of barley mutants ert-c.1 and ert-d.7 reveals two loci with additive effect on plant architecture.Planta · 2021Article
- Molecular Insights into Inflorescence Meristem Specification for Yield Potential in Cereal Crops.International journal of molecular sciences · 2021Review
8 more citing papers are in PubMed but not listed here.
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14 authors.
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Abstract
Within the cereal grasses, variation in inflorescence architecture results in a conspicuous morphological diversity that in crop species influences the yield of cereal grains. Although significant progress has been made in identifying some of the genes underlying this variation in maize and rice, in the temperate cereals, a group that includes wheat, barley, and rye, only the dosage-dependent and highly pleiotropic Q locus in hexaploid wheat has been molecularly characterized. Here we show that the characteristic variation in the density of grains along the inflorescence, or spike, of modern cultivated barley (Hordeum vulgare) is largely the consequence of a perturbed interaction between microRNA172 and its corresponding binding site in the mRNA of an APELATA2 (AP2)-like transcription factor, HvAP2. We used genome-wide association and biparental mapping to identify HvAP2. By comparing inflorescence development and HvAP2 transcript abundance in an extreme dense-spike mutant and its nearly isogenic WT line, we show that HvAP2 turnover driven by microRNA 172 regulates the length of a critical developmental window that is required for elongation of the inflorescence internodes. Our data indicate that this heterochronic change, an altered timing of developmental events caused by specific temporal variation in the efficiency of HvAP2 turnover, leads to the striking differences in the size and shape of the barley spike.
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