Evidence map›Paper›PMID 24065788›Full record

ReviewDiabetes2013

Sugar, uric acid, and the etiology of diabetes and obesity.

Richard J Johnson, Takahiko Nakagawa, L Gabriela Sanchez-Lozada, Mohamed Shafiu, Shikha Sundaram, Myphuong Le, Takuji Ishimoto, Yuri Y Sautin, Miguel A Lanaspa

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03783195 (Genetic-specific Effects of Fructose on Liver Lipogenesis), which is not on this map. Cited by 373 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
373citing papers in PubMed, 5 pooled it
33.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03783195 nacompletednot on this mapstarted 2019, after this paper: background citation

Genetic-specific Effects of Fructose on Liver Lipogenesis

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2019 to 2023Enrolled15ConditionsNAFLDArmsSugar drink
3 · Its place in the literature

Who cites it

373 citing papers in PubMed, 5 syntheses or guidelines pooled it, 730 citations in OpenAlex.

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313 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 3 countries.

Richard J JohnsonDivision of Kidney Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado.
Takahiko Nakagawa
L Gabriela Sanchez-Lozada
Mohamed Shafiu
Shikha Sundaram
Myphuong Le
Takuji Ishimoto
Yuri Y Sautin
Miguel A Lanaspa
Colorado Kidney Care · USChildren's Hospital Colorado · USInstituto Nacional de Cardiología · MXKyoto University · JPRenal Associates P. A. · USUniversity of Colorado Denver · USUniversity of Florida · USVA Eastern Colorado Health Care System · US

Funding

Non-Alcoholic Fatty Liver Disease and Obstructive Sleep Apnea: Mechanistic LinksK23DK085150 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI SUNDARAM, SHIKHA SEKSARIA · 2011 to 2015
$891k
A novel role for endogenous fructose in ischemic acute kidney injuryK01DK095930 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LANASPA GARCIA, MIGUEL ANGEL · 2012 to 2016
$686k
Fructokinase and Nondiabetic and Aging-Associated Chronic Kidney DiseaseI01BX002586 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI JOHNSON, RICHARD JOSEPH · 2015 to 2019
–
BLRD VA I01 BX002586NIDDK NIH HHS K01 DK095930NIDDK NIH HHS K23 DK085150
6 · The paper itself

Abstract

The intake of added sugars, such as from table sugar (sucrose) and high-fructose corn syrup has increased dramatically in the last hundred years and correlates closely with the rise in obesity, metabolic syndrome, and diabetes. Fructose is a major component of added sugars and is distinct from other sugars in its ability to cause intracellular ATP depletion, nucleotide turnover, and the generation of uric acid. In this article, we revisit the hypothesis that it is this unique aspect of fructose metabolism that accounts for why fructose intake increases the risk for metabolic syndrome. Recent studies show that fructose-induced uric acid generation causes mitochondrial oxidative stress that stimulates fat accumulation independent of excessive caloric intake. These studies challenge the long-standing dogma that "a calorie is just a calorie" and suggest that the metabolic effects of food may matter as much as its energy content. The discovery that fructose-mediated generation of uric acid may have a causal role in diabetes and obesity provides new insights into pathogenesis and therapies for this important disease.

Indexed as

AnimalsCardiovascular DiseasesDiabetes Mellitus, Type 2Dietary SucroseDisease Models, AnimalEnergy IntakeFatty LiverFeeding BehaviorFemaleFructoseHumansHyperuricemiaInsulin ResistanceMaleMetabolic SyndromeObesityDietary SucroseFructoseSweetening AgentsUric Acid

Identifiers

PMID24065788
PMCPMC3781481
OpenAlexW2162309758

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.