ArticleGenome research2014
Chromosome-wide profiling of X-chromosome inactivation and epigenetic states in fetal brain and placenta of the opossum, Monodelphis domestica.
Article in Genome research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 61 citations in OpenAlex.
- Review
- Pyometra with Concurrent Endometrial Adenocarcinoma in Laboratory Opossums (Monodelphis domestica): A Case Series of Four Animals.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- DNA methylation reprogramming in marsupial embryos is restricted to the extraembryonic lineage.Nature communications · 2026Article
- When cells rebel: a comparative genomics investigation into marsupial cancer susceptibility.Molecular biology and evolution · 2026Article
- Fetal inflammatory signals regulate maternal investment during marsupial pregnancy.PLoS biology · 2026Article
- X chromosome inactivation in mammals: general principles and species-specific considerations.EMBO reports · 2025Review
- Article
- Investigation of Food Marking and Contamination Behaviors Informs Feeding Practice in Research Colonies of Laboratory Opossums.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Imprinted X chromosome inactivation in marsupials: The paternal X arrives at the egg with a silent DNA methylation profile.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Review
- Article
- Origin and Evolution of Marsupial-specific Imprinting Clusters Through Lineage-specific Gene Duplications and Acquisition of Promoter Differential Methylation.Molecular biology and evolution · 2023Article
- Activation of Xist by an evolutionarily conserved function of KDM5C demethylase.Nature communications · 2022Article
- Review
- Genetic and genomic architecture in eight strains of the laboratory opossum Monodelphis domestica.G3 (Bethesda, Md.) · 2022Article
- The control of polycomb repressive complexes by long noncoding RNAs.Wiley interdisciplinary reviews. RNA · 2021Review
- Postnatal development in a marsupial model, the fat-tailed dunnart (Sminthopsis crassicaudata; Dasyuromorphia: Dasyuridae).Communications biology · 2021Article
- Koala methylomes reveal divergent and conserved DNA methylation signatures of X chromosome regulation.Proceedings. Biological sciences · 2021Article
- Article
- Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.Molecular biology and evolution · 2020Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Evidence from a few genes in diverse species suggests that X-chromosome inactivation (XCI) in marsupials is characterized by exclusive, but leaky inactivation of the paternally derived X chromosome. To study the phenomenon of marsupial XCI more comprehensively, we profiled parent-of-origin allele-specific expression, DNA methylation, and histone modifications in fetal brain and extra-embryonic membranes in the gray, short-tailed opossum (Monodelphis domestica). The majority of X-linked genes (152 of 176 genes with trackable SNP variants) exhibited paternally imprinted expression, with nearly 100% of transcripts derived from the maternal allele; whereas 24 loci (14%) escaped inactivation, showing varying levels of biallelic expression. In addition to recently reported evidence of marsupial XCI regulation by the noncoding Rsx transcript, strong depletion of H3K27me3 at escaper gene loci in the present study suggests that histone state modifications also correlate strongly with opossum XCI. In contrast to mouse, the opossum did not show an association between X-linked gene expression and promoter DNA methylation, with one notable exception. Unlike all other X-linked genes examined, Rsx was differentially methylated on the maternal and paternal X chromosomes, and expression was exclusively from the inactive (paternal) X chromosome. Our study provides the first comprehensive catalog of parent-of-origin expression status for X-linked genes in a marsupial and sheds light on the regulation and evolution of imprinted XCI in mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.