ArticlePharmaceutical research2014
Validation of anatomical models to study aerosol deposition in human nasal cavities.
Article in Pharmaceutical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- A Novel Faster-Acting, Dry Powder-Based, Naloxone Intranasal Formulation for Opioid Overdose.Pharmaceutical research · 2022Trial
- Advances in Intranasal CNS Targeting: Integrating Formulations, Devices, Computational Fluid Dynamics, and 3D Printing.Pharmaceutics · 2026Review
- Development, Fabrication and Application of a Sectioned 3D-Printed Human Nasal Cavity Model for In Vitro Nasal Spray Deposition Studies.Biomedicines · 2026Article
- In Vitro Model for Analysis of High-Flow Aerosol Delivery During Continuous Nebulization.Respiratory care · 2023Article
- Recent Options and Techniques to Assess Improved Bioavailability: In Vitro and Ex Vivo Methods.Pharmaceutics · 2023Review
- Comparison of Aerosol Deposition Between a Cynomolgus Macaque and a 3D Printed Cast Model of the Animal.Pharmaceutical research · 2023Article
- Pre-referral intranasal artesunate powder for cerebral malaria: a proof-of-concept study.Malaria journal · 2022Article
- Spray Dried Levodopa-Doped Powder Potentially for Intranasal Delivery.Pharmaceutics · 2022Article
- In Vitro Anatomical Models for Nasal Drug Delivery.Pharmaceutics · 2022Review
- Transnasal Aerosol Delivery During High-Flow Nasal Cannula Therapy.Respiratory care · 2022Article
- The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery.Pharmaceutics · 2021Article
- In Vitro Evaluation of Nasal Aerosol Depositions: An Insight for Direct Nose to Brain Drug Delivery.Pharmaceutics · 2021Review
- In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica.European radiology experimental · 2019Article
- Comparative study of simulated nebulized and spray particle deposition in chronic rhinosinusitis patients.International forum of allergy & rhinology · 2019Article
- Intranasal immunization with aluminum salt-adjuvanted dry powder vaccine.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Experimental human-like model to assess the part of viable Legionella reaching the thoracic region after nebulization.PloS one · 2017Article
- Micron-sized and submicron-sized aerosol deposition in a new ex vivo preclinical model.Respiratory research · 2016Article
- A new Strategy to Improve Drug Delivery to the Maxillary Sinuses: The Frequency Sweep Acoustic Airflow.Pharmaceutical research · 2016Article
- Impact of airborne particle size, acoustic airflow and breathing pattern on delivery of nebulized antibiotic into the maxillary sinuses using a realistic human nasal replica.Pharmaceutical research · 2014Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntranasal deposition of aerosols is often studied using in vitro nasal cavity models. However, the relevance of these models to predict in vivo human deposition has not been validated. This study compared in vivo nasal aerosol deposition and in vitro deposition in a human plastinated head model (NC1) and its replica constructed from CT-scan (NC2).
methodsTwo nebulizers (Atomisor Sonique® and Easynose®) were used to administer a 5.6 μm aerosol of (99m)Tc-DTPA to seven healthy volunteers and to the nasal models. Aerosol deposition was quantified by γ-scintigraphy in the nasal, upper nasal cavity and maxillary sinus (MS) regions. The distribution of aerosol deposition was determined along three nasal cavity axes (x, y and z).
resultsThere was no significant difference regarding aerosol deposition between the volunteers and NC1. Aerosol deposition was significantly lower in NC2 than in volunteers regarding nasal region (p < 0.05) but was similar for the upper nasal cavity and MS regions. Mean aerosol distribution for NC1 came within the standard deviation (SD) of in vivo distribution, whereas that of NC2 was outside the in vivo SD for x and y axes.
conclusionsIn conclusion, nasal models can be used to predict aerosol deposition produced by nebulizers, but their performance depends on their design.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.