SynthesisMolecular biology reports2013
Rs2200733 and rs10033464 on chromosome 4q25 confer risk of cardioembolic stroke: an updated meta-analysis.
Synthesis in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Chromosome 4q25 Variants rs2200733, rs10033464, and rs1906591 Contribute to Ischemic Stroke Risk.Molecular neurobiology · 2016Pooled it
- Genetic and epigenetic architectures of stroke: Insights from GWAS to precision medicine.Neurochemistry international · 2025Review
- Variants rs2200733 and rs6843082 Show Different Associations in Asian and Non-Asian Populations With Ischemic Stroke.Frontiers in genetics · 2022Article
- Chromosome 4q25 Variants and Age at Onset of Ischemic Stroke.Molecular neurobiology · 2017Article
- Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes.Circulation research · 2017Review
- Association Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population.Annals of rehabilitation medicine · 2016Article
- Association of GWAS-Supported Variants rs2200733 and rs6843082 on Chromosome 4q25 with Ischemic Stroke in the Southern Chinese Han Population.Journal of molecular neuroscience : MN · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent genome-wide association study elucidated that 4q25 was implicated in ischemic stroke, but subsequent studies showed inconsistent results. In order to get coincident conclusion, we investigated two SNPs (rs2200733, rs10033464) on chromosome 4q25 in 1,388 stroke patients and 1,629 controls from Chinese Han population and then performed a meta-analysis. Although we failed to detect any association between 4q25 and stroke in our case-control study, meta-analysis revealed that rs2200733 showed association with overall stroke (OR 1.18, 95 % CI 1.08-1.27), but not for rs10033464. Subsequently subgroup analysis indicated that both rs2200733 and rs10033464 conferred increased risk for cardioembolic stroke (CE stroke) (for rs2200733, OR 1.38, 95 % CI 1.26-1.51; for rs10033464, OR 1.14, 95 % CI 1.02-1.26), while rs2200733 was marginal associated with non-CE stroke (OR 1.09, 95 % CI 1.02-1.16). our results demonstrated that two SNPs (rs2200733 and rs1003346) on chromosome 4q25 were limited to the stroke of cardioembolic etiology. To confirm this conclusion, well-designed studies with larger sample size involving case-control populations with homogeneous ancestry warrant to be conducted in the future.
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