ArticleHead and neck pathology2014
An immunohistochemical panel for reliable differentiation of salivary duct carcinoma and mucoepidermoid carcinoma.
Article in Head and neck pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Reappraisal of Oncocytic Adenocarcinoma: Unveiling Its Connection to Oncocytic Variants of Salivary Duct Carcinoma and Mucoepidermoid Carcinoma Through ImmunoHisto-Molecular Perspectives.The American journal of surgical pathology · 2025Article
- Aggressive Primary Thyroid Mucoepidermoid Carcinoma with Extensive Pulmonary Involvement.Biomedicines · 2024Article
- High-grade mucoepidermoid carcinoma of the salivary gland in a bull.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023Article
- Clinicopathological and immunohistochemical behavior of ductal carcinoma of the salivary and lacrimal gland in a Mexican Mestizo population.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- 2021 Update on Diagnostic Markers and Translocation in Salivary Gland Tumors.International journal of molecular sciences · 2021Review
- High-grade mucoepidermoid carcinoma in the thyroid gland with poor prognosis.Yeungnam University journal of medicine · 2021Article
- Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.Cancer cytopathology · 2020Review
- VDR in salivary gland homeostasis and cancer.The Journal of steroid biochemistry and molecular biology · 2020Article
- Diagnostic Utility of Immunohistochemical Expressions of IMP3 Versus DOG1 and p63 in Salivary Gland Tumors.Turk patoloji dergisi · 2020Article
- Salivary Duct Carcinoma and Invasive Ductal Carcinoma of the Breast: A Comparative Immunohistochemical Study.Head and neck pathology · 2018Article
- Metastatic Salivary Ductal Carcinoma to the Mastoid Segment of the Facial Nerve.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2018Article
- Expression of Hormone Receptors and HER-2 in Benign and Malignant Salivary Gland Tumors.Head and neck pathology · 2018Article
- Mammary analogue secretory carcinoma of salivary glands: diagnostic pitfall with distinct immunohistochemical profile and molecular features.Rare tumors · 2017Article
- Androgen Receptor Signaling in Salivary Gland Cancer.Cancers · 2017Review
- Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity.Oncotarget · 2015Article
- Salivary mucoepidermoid carcinoma revisited.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Review
- Intraosseous clear cell mucoepidermoid carcinoma: A case report and evaluation.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Salivary duct carcinoma is a highly aggressive salivary gland malignancy that may be misdiagnosed as high-grade mucoepidermoid carcinoma. We utilized tissue microarrays with 78 examples of mucoepidermoid carcinoma and 47 salivary duct carcinomas to evaluate the utility of an immunohistochemical panel consisting of androgen receptor, Her2/neu, p63, and cytokeratin 5/6 in distinguishing these entities. Among all cases in the cohorts, androgen receptor was highly specific for salivary duct carcinoma, while cytokeratin 5/6 and p63 were specific for mucoepidermoid carcinoma. While the rate of unequivocal Her2/neu overexpression among the salivary duct carcinomas was low (8.9 %), discrimination of salivary duct carcinoma was enhanced when this marker was used in combination with androgen receptor due to profound sensitivity. The immunohistochemical panel was particularly efficacious at distinguishing the problematic subset of high-grade mucoepidermoid carcinomas from salivary duct carcinoma. Utilization of this set of immunohistochemical markers allows reliable differentiation of salivary duct and mucoepidermoid carcinoma, a distinction with important prognostic and therapeutic implications.
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