Evidence map›Paper›PMID 24065278›Full record

ArticleOrganic & biomolecular chemistry2013

Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors.

Jonathan G Rudick, Meg M Laakso, Ashley C Schloss, William F DeGrado

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jonathan G RudickDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. jon.rudick@stonybrook.edu.
Meg M Laakso
Ashley C Schloss
William F DeGrado

Funding

Temple University Minority Access to Research Careers (MARC) programT34GM087239 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI TANAKA, JACQUELINE C · 2009 to 2018
$5.2M
DE NOVO DESIGN OF ALPHA HELICAL BUNDLESR01GM054616 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DEGRADO, WILLIAM · 1996 to 2016
$2.4M
Tools for HIV-I Inhibition Antagonists for the CCR5 Recognition Site on gp 120F32AI080144 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI RUDICK, JONATHAN G · 2008 to 2009
$101k
NIAID NIH HHS F32 AI080144NIGMS NIH HHS R01 GM054616NIGMS NIH HHS T34 GM087239
6 · The paper itself

Abstract

Template-constrained cyclic sulfopeptides that inhibit HIV-1 entry were rationally designed based on a loop from monoclonal antibody (mAb) 412d. A focused set of sulfopeptides was synthesized using Fmoc-Tyr(SO3DCV)-OH (DCV = 2,2-dichlorovinyl). Three cyclic sulfopeptides that inhibit entry of HIV-1 and complement the activity of known CCR5 antagonists were identified.

Indexed as

CCR5 Receptor AntagonistsAnti-HIV AgentsCell LineDose-Response Relationship, DrugHIV-1HIV InfectionsHumansMicrobial Sensitivity TestsModels, MolecularMolecular StructurePeptides, CyclicStructure-Activity RelationshipSulfhydryl CompoundsAnti-HIV AgentsCCR5 Receptor AntagonistsPeptides, CyclicSulfhydryl Compounds

Identifiers

PMID24065278
PMCPMC3889485

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.