ArticleGlycoconjugate journal2014
Human tandem-repeat-type galectins bind bacterial non-βGal polysaccharides.
Article in Glycoconjugate journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Interaction of Human Peripheral NK Cells with Bacterial Polysaccharides.Doklady. Biochemistry and biophysics · 2025Article
- Features and Comparative Characteristics of Fucosylated Glycans Expression in Endothelial Glycocalyx of Placental Terminal Villi in Patients with Preeclampsia Treated with Different Antihypertensive Regimens.International journal of molecular sciences · 2023Article
- Cytosolic galectin-4 enchains bacteria, restricts their motility, and promotes inflammasome activation in intestinal epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Galectin-9 recognizes and exhibits antimicrobial activity toward microbes expressing blood group-like antigens.The Journal of biological chemistry · 2022Article
- Examining Galectin Binding Specificity Using Glycan Microarrays.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Synthesis of bodipy-labeled bacterial polysaccharides and their interaction with human dendritic cells.Glycoconjugate journal · 2021Article
- Glycan Array Technology.Advances in biochemical engineering/biotechnology · 2021Article
- Factors contributing to variability of glycan microarray binding profiles.Faraday discussions · 2019Article
- Microbe-focused glycan array screening platform.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Microarray Strategies for Exploring Bacterial Surface Glycans and Their Interactions With Glycan-Binding Proteins.Frontiers in microbiology · 2019Review
- Recognition of microbial glycans by soluble human lectins.Current opinion in structural biology · 2017Review
- Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker.International journal of molecular sciences · 2016Article
- Galectin-related protein: An integral member of the network of chicken galectins 1. From strong sequence conservation of the gene confined to vertebrates to biochemical characteristics of the chicken protein and its crystal structure.Biochimica et biophysica acta · 2016Article
- Innate immunity against molecular mimicry: Examining galectin-mediated antimicrobial activity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- Examining galectin binding specificity using glycan microarrays.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Microbial glycan microarrays define key features of host-microbial interactions.Nature chemical biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Galectins are multifunctional effectors, for example acting as regulators of cell growth via protein-glycan interactions. The observation of capacity to kill bacteria for two tandem-repeat-type galectins, which target histo-blood epitopes toward this end (Stowell et al. Nat. Med. 16:295-301, 2010), prompted us to establish an array with bacterial polysaccharides. We addressed the question whether sugar determinants other than β-galactosides may be docking sites, using human galectins-4, -8, and -9. Positive controls with histo-blood group ABH-epitopes and the E. coli 086 polysaccharide ascertained the suitability of the set-up. Significant signal generation, depending on type of galectin and polysacchride, was obtained. Presence of cognate β-galactoside-related epitopes within a polysaccharide chain or its branch will not automatically establish binding properties, and structural constellations lacking galactosides, like rhamnan, were found to be active. These data establish the array as valuable screening tool, giving direction to further functional and structural studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.