ArticleDiabetologia2014
Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families.
Article in Diabetologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Visceral Adipose Tissue Depth as a Novel Predictor for Gestational Diabetes Mellitus: A Comprehensive Meta-Analysis and Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- The relationship between air pollutants and gestational diabetes: an updated systematic review and meta-analysis.Journal of endocrinological investigation · 2023Pooled it
- Maternal vitamin D status modifies the association between GDM and offspring neurodevelopment: a prospective birth cohort study.Pediatric research · 2026Article
- Maternal and cord-blood inflammatory markers and BDNF in diabetic vs. non-diabetic pregnancies.Scientific reports · 2026Article
- Gestational diabetes mellitus and children's social-emotional development, behavioral problems, and psychological adjustment.Pediatric research · 2026Article
- Diabetes in Pregnancy and School-Age Developmental Outcomes for Offspring: A Statewide Retrospective Cohort Study.Diabetes care · 2025Article
- Association between maternal glycohemoglobin in pregnancy and adult offspring cognition: results from the Transgenerational Effects of Adult Morbidity (TEAM) Study.Journal of developmental origins of health and disease · 2025Article
- Comparison of Neurodevelopmental Status in Early Infancy of Infants of Women With and Without Gestational Diabetes Mellitus.Indian journal of pediatrics · 2023Article
- Effect of Gestational Diabetes Mellitus on the Growth, Development, and Stem Cells of Offspring.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- Hyperglycemia in Pregnancy and Women's Health in the 21st Century.International journal of environmental research and public health · 2022Review
- Physical Activity during Pregnancy: Comparisons between Objective Measures and Self-Reports in Relation to Blood Glucose Levels.International journal of environmental research and public health · 2022Observational
- Cerebral Effects of Neonatal Dysglycemia.Clinics in perinatology · 2022Review
- School performance in Danish children exposed to maternal type 1 diabetes in utero: A nationwide retrospective cohort study.PLoS medicine · 2022Article
- Integrated Multi-Omics Analysis Reveals the Effect of Maternal Gestational Diabetes on Fetal Mouse Hippocampi.Frontiers in cell and developmental biology · 2022Article
- No Clinically Relevant Memory Effects in Perinatal Hyperglycemia and Hypoglycemia: A 40-Year Follow-Up of a Small Cohort.Frontiers in public health · 2022Article
- Intrauterine hyperglycemia impairs memory across two generations.Translational psychiatry · 2021Article
- Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review.International journal of molecular sciences · 2021Review
- Observational
- Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review.International journal of obesity (2005) · 2020Review
- Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium.Diabetes care · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
aims/hypothesisThe aim of this study was to investigate the association between maternal diabetes in pregnancy and offspring cognitive ability and also to assess whether the association was due to intrauterine mechanisms or shared familial characteristics.
methodsWe linked national registers and conducted a prospective cohort study of singleton Swedish-born men to explore associations between maternal pregnancy diabetes and educational achievement at age 16 years, the age of completing compulsory education in Sweden (n = 391,545 men from 337,174 families, graduating in 1988-1997 and n = 326,033 men from 282,079 families, graduating in 1998-2009), and intelligence quotient (IQ) at the mandatory conscription examination at 18 years of age (n = 664,871 from 543,203 families).
resultsAmong non-siblings, maternal diabetes in pregnancy was associated with lower offspring cognitive ability even after adjustment for maternal age at birth, parity, education, early-pregnancy BMI, offspring birth year, gestational age and birthweight. For example, in non-siblings, the IQ of men whose mothers had diabetes in their pregnancy was on average 1.36 points lower (95% CI -2.12, -0.60) than men whose mothers did not have diabetes. In comparison, we found no such association within sibships (mean difference 1.70; 95% CI -1.80, 5.21). CONCLUSIONS/
interpretationThe association between maternal diabetes in pregnancy and offspring cognitive outcomes is likely explained by shared familial characteristics and not by an intrauterine mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.