ArticleJournal of gastroenterology2014
Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review.
Article in Journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 4 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Efficacy of a whole slide image-based prediction model for lymph node metastasis in T1 colorectal cancer: A systematic review.Journal of gastroenterology and hepatology · 2024Pooled it
- [Clinical Practice Guideline for Endoscopic Resection of Early Gastrointestinal Cancer].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2020Guideline
- Sentinel lymph node mapping procedure in T1 colorectal cancer: A systematic review of published studies.Medicine · 2019Pooled it
- Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Guideline
- Chinese expert consensus on additional surgery following endoscopic resection for early colorectal cancer (2025 edition).Cancer biology & medicine · 2026Article
- Pathological risk stratification after endoscopic resection of T1 colorectal cancer: a comparative analysis of international guidelines.Journal of minimally invasive surgery · 2026Article
- Intratumoral and peritumoral radiomics of MRI predict pathological differentiation in patients with rectal cancer.Oncology letters · 2026Article
- A novel artificial intelligence approach to the prediction of lymph node metastasis using whole-slide imaging in patients with T1 colorectal cancer.Surgical endoscopy · 2025Article
- Intravoxel incoherent motion-derived histogram analysis for quantitative evaluation of tumor budding and prognostic stratification in rectal cancer.European radiology · 2025Article
- The value and application of a poorly differentiated cluster-based Ezrin marginal score system in the prognostic assessment of colorectal cancer.Discover oncology · 2025Article
- Surveillance and Surgical Salvage Treatment for Endoscopically Removed T1 Colorectal Cancers.Gut and liver · 2025Review
- Predicting disease-free survival in locally advanced rectal cancer using a prognostic model based on pretreatment b-value threshold map and postoperative pathologic features.Japanese journal of radiology · 2025Article
- Local excision for T1 rectal cancer: A population-based study of practice patterns and oncological outcomes.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Tumor Budding as a Risk Factor for Lymph Node Metastasis and Local Recurrence in pT1 Colorectal Cancer: A Systematic Review and Meta-Analysis.Gastro hep advances · 2025Review
- Pure Well-differentiated Adenocarcinoma as a Safe Factor for Lymph Node Metastasis and Recurrence of T1 Colorectal Cancer.Journal of the anus, rectum and colon · 2025Article
- Combining Endoscopic Submucosal Dissection and Adjuvant Chemoradiotherapy or Radiotherapy for Effective Management of Rectal Cancer with Deep Submucosal Invasion: A Case Series.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024Article
- Article
- Differentiation grade as a risk factor for lymph node metastasis in T1 colorectal cancer.DEN open · 2024Article
- Predictors of early colorectal cancer metastasis to lymph nodes: providing rationale for therapy decisions.Frontiers in oncology · 2024Review
- Grades of Poorly Differentiated Clusters are Associated with Lymph Node and the Tumour, Node and Metastasis Stages in Colorectal Carcinoma.The Malaysian journal of medical sciences : MJMS · 2023Article
Corrections and comments
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Authors and funding
18 authors at 13 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNovel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases.
methodsA pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike's information criterion (AIC).
resultsPDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48).
conclusionsPDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases.
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