ArticleNaunyn-Schmiedeberg's archives of pharmacology2014
Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Essential Oils: Chemistry and Mechanisms of Anticonvulsant Action.International journal of molecular sciences · 2026Review
- Combining anxiolytic activity of thymol and trans-ferulic acid: a potential GABAergic intervention.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Broad-spectrum antimicrobial activity of a citric acid-phenolic formulation in animal feed matrices.Frontiers in microbiology · 2026Article
- Monoterpenoid synergy: a new frontier in biological applications.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action.Frontiers in pharmacology · 2024Review
- Eugenol and lidocaine inhibit voltage-gated NaFrontiers in pharmacology · 2024Article
- Treating Epilepsy with Natural Products: Nonsense or Possibility?Pharmaceuticals (Basel, Switzerland) · 2023Review
- Neuronal Differentiation and Outgrowth Effect of Thymol inInternational journal of molecular sciences · 2023Article
- Newly Synthesized Thymol Derivative and Its Effect on Colorectal Cancer Cells.Molecules (Basel, Switzerland) · 2022Article
- Determination of Thymol in Commercial Formulation, Essential Oils, Traditional, and Ultrasound-Based Extracts ofMolecules (Basel, Switzerland) · 2022Article
- Extract ofFrontiers in cellular neuroscience · 2022Article
- Article
- Thymol Nanopolymer Synthesis and Its Effects on Morphine Withdrawal Syndrome in Comparison With Clonidine in Rats.Frontiers in behavioral neuroscience · 2022Article
- PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability.Metabolic brain disease · 2021Review
- Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy.Biomolecules · 2019Review
- The Healing Effects of Hydroalcoholic Extract ofIranian journal of medical sciences · 2019Article
- Assessment of luteolin isolated from Eclipta alba leaves in animal models of epilepsy.Pharmaceutical biology · 2017Article
- Monoterpenoids (thymol, carvacrol and S-(+)-linalool) with anesthetic activity in silver catfish (Rhamdia quelen): evaluation of acetylcholinesterase and GABAergic activity.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Anticonvulsive activity of (1S)-(-)-verbenone involving RNA expression of BDNF, COX-2, and c-fos.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development.Frontiers in pharmacology · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was to investigate the anticonvulsant and antiepileptogenic potential of thymol. Anticonvulsant activity of thymol (5-100 mg/kg i.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also studied for its effect on locomotion. Antiepileptogenic property of thymol (5-25 mg/kg) was evaluated using PTZ-induced kindling model along with its effect on malondialdehyde and glutathione levels. Thymol (50 and 100 mg/kg, i.p.) showed anticonvulsant activity against maximal electroshock and pentylenetetrazole (66.66 and 83.33 % protection at 50 and 100 mg/kg, respectively) model but not against strychnine and 4-aminopyridine models. Thymol exhibited decreased locomotor activity in dose-dependent manner at the same dose range. Thymol at the dose of (25 mg/kg, i.p.) significantly decreased the seizure score, increased glutathione levels and decreased malondialdehyde levels in pentylenetetrazole-induced kindling model. Thymol exhibited significant anticonvulsant and antiepileptogenic property.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.