ArticleJournal of biomedical optics2013
Laser speckle contrast imaging of blood flow in rat retinas using an endoscope.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Handheld laser speckle contrast imaging probe: quantitative video rate assessment of tissue perfusion in animal and patient applications.Biophotonics discovery · 2025Article
- Dynamic light scattering and laser speckle contrast imaging of the brain: theory of the spatial and temporal statistics of speckle pattern evolution.Biomedical optics express · 2024Article
- Measurements of slow tissue dynamics with short-separation speckle contrast optical spectroscopy.Biomedical optics express · 2023Article
- Random matrix-based laser speckle contrast imaging enables quasi-3D blood flow imaging in laparoscopic surgery.Biomedical optics express · 2023Article
- Direct characterization of tissue dynamics with laser speckle contrast imaging.Biomedical optics express · 2022Article
- Multi-scale laser speckle contrast imaging of microcirculatory vasoreactivity.Biomedical optics express · 2022Article
- Development of a Preclinical Laser Speckle Contrast Imaging Instrument for Assessing Systemic and Retinal Vascular Function in Small Rodents.Translational vision science & technology · 2021Article
- Comprehensive review of surgical microscopes: technology development and medical applications.Journal of biomedical optics · 2021Review
- Clinical applications of laser speckle contrast imaging: a review.Journal of biomedical optics · 2019Review
- Multiple speckle exposure imaging for the study of blood flow changes induced by functional activation of barrel cortex and olfactory bulb in mice.Neurophotonics · 2019Article
- Dual-display laparoscopic laser speckle contrast imaging for real-time surgical assistance.Biomedical optics express · 2018Article
- Postharvest Monitoring of Tomato Ripening Using the Dynamic Laser Speckle.Sensors (Basel, Switzerland) · 2018Article
- Monitoring blood-flow in the mouse cochlea using an endoscopic laser speckle contrast imaging system.PloS one · 2018Article
- Rat retinal vasomotion assessed by laser speckle imaging.PloS one · 2017Article
- Laser Speckle Contrast Imaging to Evaluate Bowel Lesions in Neonates with NEC.European journal of pediatric surgery reports · 2017Article
- Laser speckle analysis of retinal vascular dynamics.Biomedical optics express · 2016Article
- Noninvasive assessment of hemodynamic and brain metabolism parameters following closed head injury in a mouse model by comparative diffuse optical reflectance approaches.Neurophotonics · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Laser speckle contrast imaging (LSCI) offers a cost-effective means to image blood flow in vivo. However, it is not commonly used to image rodent retinas because of the challenges associated with imaging through the curved cornea and delivering light through the highly scattering lens. A solution to overcome these problems by using LSCI in conjunction with an endoscope to obtain high spatiotemporal blood flow images is described. Its utility is demonstrated by imaging blood flow changes in rat retinas using hyperoxic, hypercapnic, and visual (flicker) stimulations. Hypercapnia increases blood flow, hyperoxia decreases blood flow, and visual stimulation increases blood flow in the retina relative to basal conditions. The time-to-peak of the LSCI response to visual stimulation is also measured. This approach may prove useful to investigate dysregulation in blood flow-evoked responses in retinal diseases and to evaluate treatment strategies in rodents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.