ArticleAmerican journal of epidemiology2013
Age-period-cohort analysis of trends in amyotrophic lateral sclerosis in Denmark, 1970-2009.
Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02869048 (Amyotrophic Lateral Sclerosis and the Innate Immune System), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Amyotrophic Lateral Sclerosis and the Innate Immune System
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global Prevalence and Incidence of Amyotrophic Lateral Sclerosis: A Systematic Review.Neurology · 2023Pooled it
- Mortality From Amyotrophic Lateral Sclerosis in Finland 1987-2022.European journal of neurology · 2026Article
- Cutting-edge treatments in amyotrophic lateral sclerosis: the role of molecular pathogenesis in targeted therapies.Stem cell research & therapy · 2025Review
- Sex-related differences in amyotrophic lateral sclerosis: A 2-[European journal of neurology · 2025Article
- Age-period-cohort effect on motor neuron disease mortality in the United States, 2001-2020.Frontiers in neurology · 2025Article
- The burden of motor neuron diseases in Asia, 1990-2021: temporal patterns and age-period-cohort analyses.Frontiers in neurology · 2025Article
- Analysis of incidence of motor neuron disease in England 1998-2019: use of three linked datasets.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2022Article
- ALS in Danish Registries: Heritability and links to psychiatric and cardiovascular disorders.Neurology. Genetics · 2020Article
- Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark.Occupational and environmental medicine · 2019Article
- Gene-Environment-Time Interactions in Neurodegenerative Diseases: Hypotheses and Research Approaches.Annals of neurosciences · 2018Article
- Amyotrophic Lateral Sclerosis and Exposure to Diesel Exhaust in a Danish Cohort.American journal of epidemiology · 2018Article
- Spatial analyses of ALS incidence in Denmark over three decades.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2018Article
- Secular Trends of Amyotrophic Lateral Sclerosis: The Piemonte and Valle d'Aosta Register.JAMA neurology · 2017Article
- Mortality trends of amyotrophic lateral sclerosis in Norway 1951-2014: an age-period-cohort study.Journal of neurology · 2016Article
- Age-period-cohort analysis of trends in amyotrophic lateral sclerosis incidence.Journal of neurology · 2016Article
- Time Trends in the Incidence of Parkinson Disease.JAMA neurology · 2016Article
- Primary Lateral Sclerosis and Early Upper Motor Neuron Disease: Characteristics of a Cross-Sectional Population.Journal of clinical neuromuscular disease · 2016Article
- A Temporal Association between Accumulated Petrol (Gasoline) Lead Emissions and Motor Neuron Disease in Australia.International journal of environmental research and public health · 2015Article
- Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis: A Population-Based Study.JAMA neurology · 2015Article
- Comparison of diagnoses of amyotrophic lateral sclerosis by use of death certificates and hospital discharge data in the Danish population.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Amyotrophic lateral sclerosis (ALS) is a disease of the motor neuron with poorly understood etiology. Recent studies have suggested that the incidence rate of ALS and the rate of death from ALS are increasing, but it is unclear whether this is due to changing exposures or improvements in diagnosis. We used age-period-cohort models to investigate trends in ALS incidence (hospitalization) from 1982 to 2009 and ALS mortality from 1970 to 2009 in Denmark. Among those 45 years of age or older, 4,265 deaths (incidence rate = 5.35 per 100,000 person-years) and 3,228 incident diagnoses (incidence rate = 5.55 per 100,000 person-years) were recorded. Age-adjusted mortality rates increased by an average of 3.0% annually between 1970 and 2009 and by an average of 2.1% annually after 1982. Age-period-cohort analyses suggested that the full age-period-cohort model provided the best fit to the mortality data (P < 0.001), although restriction to the post-1982 period suggested that the age-cohort model provided the best fit. Age-adjusted incidence rates increased by 1.6% annually after 1982 (P < 0.001), which was best explained by the age-period model, with borderline significant cohort effects (P = 0.08). A consistent finding regardless of parameterization or data subset appeared to be an increase in ALS incidence and mortality rate with later birth cohorts, up to a birth year of at least 1910.
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