ArticleMolecules (Basel, Switzerland)2013
A modular approach to triazole-containing chemical inducers of dimerisation for yeast three-hybrid screening.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates.ACS omega · 2023Article
- NovelFrontiers in chemistry · 2022Article
- Structure-activity relationship studies of lipophilic teicoplanin pseudoaglycon derivatives as new anti-influenza virus agents.European journal of medicinal chemistry · 2018Article
- Charged Triazole Cross-Linkers for Hyaluronan-Based Hybrid Hydrogels.Materials (Basel, Switzerland) · 2016Article
- Yeast three-hybrid screen identifies TgBRADIN/GRA24 as a negative regulator of Toxoplasma gondii bradyzoite differentiation.PloS one · 2015Article
- Article
- Target identification strategies in plant chemical biology.Frontiers in plant science · 2014Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The yeast three-hybrid (Y3H) approach shows considerable promise for the unbiased identification of novel small molecule-protein interactions. In recent years, it has been successfully used to link a number of bioactive molecules to novel protein binding partners. However despite its potential importance as a protein target identification method, the Y3H technique has not yet been widely adopted, in part due to the challenges associated with the synthesis of the complex chemical inducers of dimerisation (CIDs). The development of a modular approach using potentially "off the shelf" synthetic components was achieved and allowed the synthesis of a family of four triazole-containing CIDs, MTX-Cmpd2.2-2.5. These CIDs were then compared using the Y3H approach with three of them giving a strong positive interaction with a known target of compound 2, TgCDPK1. These results showed that the modular nature of our synthetic strategy may help to overcome the challenges currently encountered with CID synthesis and should contribute to the Y3H approach reaching its full potential as an unbiased target identification strategy.
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Registered trials
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