ReviewMolecules (Basel, Switzerland)2013
Revealing the properties of plant defensins through dynamics.
Review in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- Plant Defensins from a Structural Perspective.International journal of molecular sciences · 2020Review
- Article
- Structural and Dynamic Insights of the Interaction between Tritrpticin and Micelles: An NMR Study.Biophysical journal · 2016Article
- Antifungal defensins and their role in plant defense.Frontiers in microbiology · 2014Review
- Overexpression of a defensin enhances resistance to a fruit-specific anthracnose fungus in pepper.PloS one · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Defensins are potent, ancient natural antibiotics that are present in organisms ranging from lower organisms to humans. Although the structures of several defensins have been well characterized, the dynamics of only a few have been studied. This review discusses the diverse dynamics of two plant defensins for which the structure and dynamics have been characterized, both in the free state and in the presence of target membranes. Multiple motions are observed in loops and in secondary structure elements and may be related to twisting or breathing of the α-helix and β-sheet. This complex behavior is altered in the presence of an interface and is responsive to the presence of the putative target. The stages of membrane recognition and disruption can be mapped over a large time scale range, demonstrating that defensins in solution exist as an ensemble of different conformations, a subset of which is selected upon membrane binding. Therefore, studies on the dynamics have revealed that defensins interact with membranes through a mechanism of conformational selection.
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