ArticleEndocrinology2013
Dlk1 up-regulates Gli1 expression in male rat adrenal capsule cells through the activation of β1 integrin and ERK1/2.
Article in Endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma.Nature communications · 2025Article
- Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma.Cancer communications (London, England) · 2025Article
- The Hira complex regulates Gli3R-dependent transcription in Hedgehog signaling and medulloblastoma cell growth and migration.Scientific reports · 2025Article
- Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma.bioRxiv : the preprint server for biology · 2024Article
- Single-nucleus and spatial transcriptome reveal adrenal homeostasis in normal and tumoural adrenal glands.Clinical and translational medicine · 2024Article
- The 3D in vitro Adrenoid cell model recapitulates the complexity of the adrenal gland.Scientific reports · 2024Article
- Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging Therapies.Endocrine reviews · 2022Article
- [Adrenal glands stem cells: general signaling pathways].Problemy endokrinologii · 2021Article
- Stem cell function and plasticity in the normal physiology of the adrenal cortex.Molecular and cellular endocrinology · 2021Review
- Embryonic Development and Adult Regeneration of the Adrenal Gland.Endocrinology and metabolism (Seoul, Korea) · 2020Review
- DLK1/PREF1 marks a novel cell population in the human adrenal cortex.The Journal of steroid biochemistry and molecular biology · 2019Article
- Regulation of stem and progenitor cells in the adrenal cortex.Current opinion in endocrine and metabolic research · 2019Article
- ACTH signalling and adrenal development: lessons from mouse models.Endocrine connections · 2019Review
- Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System.Frontiers in endocrinology · 2019Review
- Involvement of DHH and GLI1 in adrenocortical autograft regeneration in rats.Scientific reports · 2018Article
- MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal.JCI insight · 2018Article
- Targeted Disruption of YAP and TAZ Impairs the Maintenance of the Adrenal Cortex.Endocrinology · 2017Article
- A genomic atlas of human adrenal and gonad development.Wellcome open research · 2017Article
- Regulation of zonation and homeostasis in the adrenal cortex.Molecular and cellular endocrinology · 2017Review
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7 authors at 2 institutions in 1 country.
Funding
Abstract
The development and maintenance of the zones of the adrenal cortex and their steroidal output are extremely important in the control of gluconeogenesis, the stress response, and blood volume. Sonic Hedgehog (Shh) is expressed in the adrenal cortex and signals to capsular cells, which can respond by migrating into the cortex and converting into a steroidogenic phenotype. Delta-like homologue 1 (Dlk1), a member of the Notch/Delta/Serrate family of epidermal growth factor-like repeat-containing proteins, has a well-established role in inhibiting adipocyte differentiation. We demonstrate that Shh and Dlk1 are coexpressed in the outer undifferentiated zone of the male rat adrenal and that Dlk1 signals to the adrenal capsule, activating glioma-associated oncogene homolog 1 transcription in a β1 integrin- and Erk1/2-dependent fashion. Moreover, Shh and Dlk1 expression inversely correlates with the size of the zona glomerulosa in rats after manipulation of the renin-angiotensin system, suggesting a role in the homeostatic maintenance of the gland.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.