Evidence map›Paper›PMID 24064151›Full record

ArticleThe Journal of pediatrics2014

Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease.

Stavra A Xanthakos, Daniel J Podberesky, Suraj D Serai, Lili Miles, Eileen C King, William F Balistreri, Rohit Kohli

Registry-linked trialOpen access · bronzeAbstract readComparative Study
In one paragraph

Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03027700 (Comparison of Non-invasive Methods to Detect and Quantify Liver Fibrosis), which is not on this map. Cited by 69 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 5 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03027700 naterminatednot on this mapstarted 2017, after this paper: background citation

Comparison of Non-invasive Methods to Detect and Quantify Liver Fibrosis

TypeinterventionalSponsorChildren's Hospital Medical Center, CincinnatiRan2017 to 2018Enrolled6ConditionsLiver Fibroses, Hepatic SteatosisArmsMRI
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 137 citations in OpenAlex.

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  14. The combined pioglitazone and topiramate therapy for management of pediatric patients with severe MASLD.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stavra A XanthakosSteatohepatitis Center, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address: stavra.xanthakos@cchmc.org.
Daniel J PodbereskyDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Suraj D SeraiDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Lili MilesDepartment of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Eileen C KingDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
William F BalistreriSteatohepatitis Center, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Rohit KohliSteatohepatitis Center, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Cincinnati Children's Hospital Medical Center · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Theresa Alenghat · 2007 to 2026
$24.4M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
Biological Determinants of Steatohepatitis after Adolescent Bariatric SurgeryK23DK080888 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI XANTHAKOS, STAVRA · 2008 to 2012
$886k
Role of Ileum in Reducing Obesity Related ComorbiditiesK08DK084310 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI KOHLI, ROHIT · 2009 to 2013
$602k
NCATS NIH HHS 8 UL1 TR000077-04NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR001425NIDDK NIH HHS K08 DK084310NIDDK NIH HHS K08DK084310NIDDK NIH HHS K23 DK080888NIDDK NIH HHS K23DK080888NIDDK NIH HHS P30 DK078392
6 · The paper itself

Abstract

Management of pediatric chronic liver disease is limited by lack of validated noninvasive biomarkers of histologic severity. We demonstrate that magnetic resonance elastography is feasible and accurate in detecting significant hepatic fibrosis in a case series of 35 children with chronic liver disease, including severely obese children.

Indexed as

AdolescentChildChild, PreschoolChronic DiseaseElasticity Imaging TechniquesFemaleHumansLiver CirrhosisLiver DiseasesMagnetic Resonance ImagingMaleReproducibility of ResultsRetrospective StudiesROC CurveSeverity of Illness IndexYoung AdultAcoustic radiation force imagingArea under the receiver operating characteristic curveARFIAUROCBMIBody mass indexMagnetic resonance elastographyMRENAFLDNASHNonalcoholic fatty liver diseaseNonalcoholic steatohepatitisRegion of interestROITETransient elastographyUltrasoundUS

Identifiers

PMID24064151
PMCPMC3872246
OpenAlexW2054664446

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.