ArticleBone2013
The plastic nature of the human bone-periodontal ligament-tooth fibrous joint.
Article in Bone, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Guidance on biomaterials for periodontal tissue regeneration: Fabrication methods, materials and biological considerations.Dental materials : official publication of the Academy of Dental Materials · 2025Review
- Atomic force microscopy-mediated mechanobiological profiling of complex human tissues.Biomaterials · 2023Review
- Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review.Dentistry journal · 2023Review
- Discovering genetic linkage between periodontitis and type 1 diabetes: A bioinformatics study.Frontiers in genetics · 2023Article
- Between a rock and a hard place: Regulation of mineralization in the periodontium.Genesis (New York, N.Y. : 2000) · 2022Review
- Assessment of Dimensional Changes in Periodontium with Immediate Replacement of Tooth by Socket-shield Technique.Journal of pharmacy & bioallied sciences · 2022Article
- The effect of aging on the nanostructure of murine alveolar bone and dentin.Journal of bone and mineral metabolism · 2021Article
- Article
- Mechanoadaptive Responses in the Periodontium Are Coordinated by Wnt.Journal of dental research · 2019Article
- The Mechanical Effect of the Periodontal Ligament on Bone Strain Regimes in a Validated Finite Element Model of a Macaque Mandible.Frontiers in bioengineering and biotechnology · 2019Article
- Micropatterned Scaffolds with Immobilized Growth Factor Genes Regenerate Bone and Periodontal Ligament-Like Tissues.Advanced healthcare materials · 2018Article
- A Force on the Crown and Tug of War in the Periodontal Complex.Journal of dental research · 2018Review
- Evaluation of in vivo digital root reconstruction based on anatomical characteristics of the periodontal ligament using cone beam computed tomography.Scientific reports · 2018Article
- Periodontal ligament entheses and their adaptive role in the context of dentoalveolar joint function.Dental materials : official publication of the Academy of Dental Materials · 2017Review
- Effect of proteoglycans at interfaces as related to location, architecture, and mechanical cues.Archives of oral biology · 2016Article
- Multiscale biomechanical responses of adapted bone-periodontal ligament-tooth fibrous joints.Bone · 2015Article
- Strain-guided mineralization in the bone-PDL-cementum complex of a rat periodontium.Bone reports · 2015Article
- Mechanical Forces Exacerbate Periodontal Defects in Bsp-null Mice.Journal of dental research · 2015Article
- Article
- Adaptive properties of human cementum and cementum dentin junction with age.Journal of the mechanical behavior of biomedical materials · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
This study investigates bony protrusions within a narrowed periodontal ligament space (PDL-space) of a human bone-PDL-tooth fibrous joint by mapping structural, biochemical, and mechanical heterogeneity. Higher resolution structural characterization was achieved via complementary atomic force microscopy (AFM), nano-transmission X-ray microscopy (nano-TXM), and microtomography (MicroXCT™). Structural heterogeneity was correlated to biochemical and elemental composition, illustrated via histochemistry and microprobe X-ray fluorescence analysis (μ-XRF), and mechanical heterogeneity evaluated by AFM-based nanoindentation. Results demonstrated that the narrowed PDL-space was due to invasion of bundle bone (BB) into PDL-space. Protruded BB had a wider range with higher elastic modulus values (2-8GPa) compared to lamellar bone (0.8-6GPa), and increased quantities of Ca, P and Zn as revealed by μ-XRF. Interestingly, the hygroscopic 10-30μm interface between protruded BB and lamellar bone exhibited higher X-ray attenuation similar to cement lines and lamellae within bone. Localization of the small leucine rich proteoglycan biglycan (BGN) responsible for mineralization was observed at the PDL-bone interface and around the osteocyte lacunae. Based on these results, it can be argued that the LB-BB interface was the original site of PDL attachment, and that the genesis of protruded BB identified as protrusions occurred as a result of shift in strain. We emphasize the importance of bony protrusions within the context of organ function and that additional study is warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.